UNIGE document Scientific Article
previous document  unige:44643  next document
add to browser collection
Title

Survival and cure trends for European children, adolescents and young adults diagnosed with acute lymphoblastic leukemia from 1982 to 2002

Authors
Gatta, Gemma
Rossi, Silvia
Foschi, Roberto
Trama, Annalisa
Marcos-Gragera, Rafael
Pastore, Guido
Peris-Bonet, Rafael
Stiller, Charles
show hidden authors show all authors [1 - 9]
CollaborationWith : Usel, Massimo
Published in Haematologica. 2013, vol. 98, no. 5, p. 744-52
Abstract Proportion cured is a potentially more informative cancer outcome measurement than 5-year survival. We present population-based estimates of cure for young patients diagnosed with acute lymphoblastic leukemia in Europe from 1982 to 2002. Thirty-five European cancer registries provided data. Survival was estimated by age, period of diagnosis and European region, and used as input for parametric cure models, which assume cured patients have the same mortality as the general population. For acute lymphoblastic leukemia diagnosed in 1-14 year olds in 2000-2002, over 77% were estimated cured. The proportion cured improved significantly over the study period: an impressive 26-58% in infants (up to 1 year), 70-90% in 1-4 year olds, 63-86% in 5-9 year olds, 52-77% in 10-14 year olds, and 44-50% in 15-24 year olds. Regional variations in proportion cured reduced over time for 1-14 year-olds, but persisted in infants and 15-24 year olds. Five-year survival was always slightly higher than proportion cured. Considerable proportions of young patients were estimated cured of acute lymphoblastic leukemia. Nevertheless, a small excess risk of death persisted beyond five years after diagnosis when patients remained at risk for late treatment effects, late relapses and second primaries.
Keywords AdolescentAge FactorsChildChild, PreschoolEurope/epidemiologyFemaleHistory, 20th CenturyHistory, 21st CenturyHumansInfantInfant, NewbornMalePrecursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology/history/mortalityRegistriesYoung Adult
Identifiers
PMID: 23403323
Full text
Article (Published version) (1.3 MB) - public document Free access
Structures
Research group Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
Citation
(ISO format)
GATTA, Gemma et al. Survival and cure trends for European children, adolescents and young adults diagnosed with acute lymphoblastic leukemia from 1982 to 2002. In: Haematologica, 2013, vol. 98, n° 5, p. 744-52. https://archive-ouverte.unige.ch/unige:44643

178 hits

124 downloads

Update

Deposited on : 2015-01-07

Export document
Format :
Citation style :