UNIGE document Professional Article - Case report
previous document  unige:44629  next document
add to browser collection
Title

Nephrogenic fibrosing dermopathy in a renal transplant recipient with tubulointerstitial nephritis and uveitis

Authors
Published in Dermatology. 2004, vol. 209, no. 1, p. 50-2
Abstract We report a patient with nephrogenic fibrosing dermopathy. He had chronic renal failure with arthritis, uveitis and histologically severe tubulointerstitial nephritis for which he received a renal transplant from a family relative. After an episode of acute renal failure with the transplant he developed painful, erythematous, firm papules and plaques with geographic borders on the legs, anterior thorax and elbow. A skin biopsy revealed increased fibroblast and collagen fiber content of the dermis and subcutaneous septae. Mucin deposition, sparse smooth-muscle-actin-positive cells and an increased number of CD34-positive cells in the deep dermis were found. After several weeks of hemodialysis, the lesions changed from an inflammatory to a purely sclerotic phase. The fibrocyte, a recently described circulating cell type, that is deposited in scar tissue may be involved in the pathogenesis of this novel pseudosclerodermatous skin disorder.
Keywords Diagnosis, DifferentialElbowFibrosis/complications/diagnosis/pathologyHumansKidney TransplantationLegMaleMiddle AgedNephritis, Interstitial/complicationsSkin Diseases/complications/diagnosis/pathologyThoraxUveitis/complications
Identifiers
PMID: 15237268
Full text
Article (Published version) (97 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group La matrice extracellulaire (651)
Citation
(ISO format)
HAUSER, Conrad, KAYA, Gurkan, CHIZZOLINI, Carlo. Nephrogenic fibrosing dermopathy in a renal transplant recipient with tubulointerstitial nephritis and uveitis. In: Dermatology, 2004, vol. 209, n° 1, p. 50-2. https://archive-ouverte.unige.ch/unige:44629

155 hits

0 download

Update

Deposited on : 2015-01-07

Export document
Format :
Citation style :