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Title

Nephrogenic fibrosing dermopathy in a renal transplant recipient with tubulointerstitial nephritis and uveitis
Authors
Hauser, Conrad
Kaya, Guerkan
Chizzolini, Carlo
Published in Dermatology. 2004, vol. 209, no. 1, p. 50-2
Abstract We report a patient with nephrogenic fibrosing dermopathy. He had chronic renal failure with arthritis, uveitis and histologically severe tubulointerstitial nephritis for which he received a renal transplant from a family relative. After an episode of acute renal failure with the transplant he developed painful, erythematous, firm papules and plaques with geographic borders on the legs, anterior thorax and elbow. A skin biopsy revealed increased fibroblast and collagen fiber content of the dermis and subcutaneous septae. Mucin deposition, sparse smooth-muscle-actin-positive cells and an increased number of CD34-positive cells in the deep dermis were found. After several weeks of hemodialysis, the lesions changed from an inflammatory to a purely sclerotic phase. The fibrocyte, a recently described circulating cell type, that is deposited in scar tissue may be involved in the pathogenesis of this novel pseudosclerodermatous skin disorder.
Keywords Diagnosis, Differential — Elbow — Fibrosis/complications/diagnosis/pathology — Humans — Kidney Transplantation — Leg — Male — Middle Aged — Nephritis, Interstitial/complications — Skin Diseases/complications/diagnosis/pathology — Thorax — Uveitis/complications
Identifiers
PMID: 15237268
Full text
Article (Published version) (97 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Research group La matrice extracellulaire (651)
Citation
(ISO format) 		HAUSER, Conrad, KAYA, Guerkan, CHIZZOLINI, Carlo. Nephrogenic fibrosing dermopathy in a renal transplant recipient with tubulointerstitial nephritis and uveitis. In: Dermatology, 2004, vol. 209, n° 1, p. 50-2. https://archive-ouverte.unige.ch/unige:44629

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Deposited on : 2015-01-07

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