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Nephrogenic fibrosing dermopathy in a renal transplant recipient with tubulointerstitial nephritis and uveitis

Published inDermatology, vol. 209, no. 1, p. 50-52
Publication date2004
Abstract

We report a patient with nephrogenic fibrosing dermopathy. He had chronic renal failure with arthritis, uveitis and histologically severe tubulointerstitial nephritis for which he received a renal transplant from a family relative. After an episode of acute renal failure with the transplant he developed painful, erythematous, firm papules and plaques with geographic borders on the legs, anterior thorax and elbow. A skin biopsy revealed increased fibroblast and collagen fiber content of the dermis and subcutaneous septae. Mucin deposition, sparse smooth-muscle-actin-positive cells and an increased number of CD34-positive cells in the deep dermis were found. After several weeks of hemodialysis, the lesions changed from an inflammatory to a purely sclerotic phase. The fibrocyte, a recently described circulating cell type, that is deposited in scar tissue may be involved in the pathogenesis of this novel pseudosclerodermatous skin disorder.

Keywords
  • Diagnosis, Differential
  • Elbow
  • Fibrosis/complications/diagnosis/pathology
  • Humans
  • Kidney Transplantation
  • Leg
  • Male
  • Middle Aged
  • Nephritis, Interstitial/complications
  • Skin Diseases/complications/diagnosis/pathology
  • Thorax
  • Uveitis/complications
Citation (ISO format)
HAUSER, Conrad, KAYA, Guerkan, CHIZZOLINI, Carlo. Nephrogenic fibrosing dermopathy in a renal transplant recipient with tubulointerstitial nephritis and uveitis. In: Dermatology, 2004, vol. 209, n° 1, p. 50–52. doi: 10.1159/000078587
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ISSN of the journal1018-8665
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