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Scientific article
Open access
English

Efficacy of TNF {alpha} blockade in cyclophosphamide resistant neuro-Behçet disease

Published inJournal of neurology, neurosurgery and psychiatry, vol. 76, no. 12, p. 1733-1735
Publication date2005
Abstract

Behçet disease is a chronic relapsing inflammatory condition, predominantly affecting young adults, characterised by recurrent bipolar aphtae and systemic manifestations for which tumour necrosis factor (TNF) alpha blockade has recently emerged as an effective treatment. We report the case of a patient presenting with mucocutaneous and ocular manifestations who in the course of his disease developed CNS parenchymal involvement. While being treated with pulsed cyclophosphamide and corticosteroids, he suffered a relapse of his CNS involvement that was efficaciously controlled by infliximab. No disease activity was observed during a full year of TNF blockade, associated with azathioprine, colchicine, and corticosteroids. However, 7 months after the last administration of infliximab and still under immunosuppressant agents, CNS lesions recurred. Infliximab was successfully reintroduced and since continued with no side effects. The sequence of events observed in this patient suggests that TNF blockade is efficacious in suppressing neuro-Behçet disease and once introduced should be maintained for a prolonged period of time.

Keywords
  • Adult
  • Antibodies, Monoclonal/therapeutic use
  • Antirheumatic Agents/therapeutic use
  • Behcet Syndrome/drug therapy/immunology/pathology
  • Cyclophosphamide/pharmacology/therapeutic use
  • Humans
  • Immunosuppressive Agents/pharmacology/therapeutic use
  • Male
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha/antagonists & inhibitors
Citation (ISO format)
RIBI, Camillo et al. Efficacy of TNF {alpha} blockade in cyclophosphamide resistant neuro-Behçet disease. In: Journal of neurology, neurosurgery and psychiatry, 2005, vol. 76, n° 12, p. 1733–1735. doi: 10.1136/jnnp.2004.055434
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0022-3050
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