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Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis?

ContributorsEnrichot, Elvire; Juge-Aubry, Cristiana E; Pernin, Agnès; Pache, Jean-Claude; Velebit, Valdimir; Dayer, Jean-Michel; Meda, Paolo; Chizzolini, Carlo; Meier, Christoph A
Published inArteriosclerosis, thrombosis, and vascular biology, vol. 25, no. 12, p. 2594-2599
Publication date2005
Abstract

Obesity is associated with an increased risk for cardiovascular disease. Although it is known that white adipose tissue (WAT) produces numerous proinflammatory and proatherogenic cytokines and chemokines, it is unclear whether adipose-derived chemotactic signals affect the chronic inflammation in atherosclerosis.

Keywords
  • Adipose Tissue/cytology/immunology/metabolism
  • Animals
  • Aorta/pathology
  • Atherosclerosis/immunology/metabolism
  • Cells, Cultured
  • Chemokine CCL2/metabolism/secretion
  • Chemotaxis, Leukocyte/immunology
  • Diet, Atherogenic
  • Dietary Fats/pharmacology
  • Granulocytes/cytology
  • Humans
  • Interleukin-8/metabolism/secretion
  • Monocytes/cytology
  • Obesity/immunology/metabolism
  • Rats
  • Rats, Wistar
Affiliation entities
Research groups
Citation (ISO format)
ENRICHOT, Elvire et al. Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis? In: Arteriosclerosis, thrombosis, and vascular biology, 2005, vol. 25, n° 12, p. 2594–2599. doi: 10.1161/01.ATV.0000188508.40052.35
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accessLevelPublic
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Journal ISSN1079-5642
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836downloads

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