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Epilepsy and cerebellar ataxia associated with anti-glutamic acid decarboxylase antibodies

Published in Journal of Neurology, Neurosurgery, and Psychiatry. 2007, vol. 78, no. 2, p. 187-9
Abstract Anti-glutamic acid decarboxylase (GAD) antibodies are described in stiff-person syndrome and also in other neurological syndromes, including cerebellar ataxia and epilepsy. This paper reports the case of a patient who had chronic focal epilepsy, upbeat nystagmus and cerebellar ataxia, associated with a polyautoimmune response including anti-GAD antibodies. Both gait and nystagmus improved markedly after immunosuppressive treatment with corticosteroids and azathioprine. After the introduction of benzodiazepines, previously refractory seizures were completely controlled. Anti-GAD antibodies should be actively sought out in pharmacoresistant epilepsy, particularly if other neurological abnormalities are present. Combined treatment with immunosuppressants and gammahydroxybutyric acidergic agents may be highly effective.
Keywords Adrenal Cortex Hormones/therapeutic useAutoantibodiesAzathioprine/therapeutic useCerebellar Ataxia/drug therapy/immunologyEpilepsy/drug therapy/immunologyGlutamate Decarboxylase/immunologyHumansImmunosuppressive Agents/therapeutic useMaleMiddle AgedNystagmus, PathologicTreatment Outcome
PMID: 17229747
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VULLIEMOZ, Serge et al. Epilepsy and cerebellar ataxia associated with anti-glutamic acid decarboxylase antibodies. In: Journal of Neurology, Neurosurgery, and Psychiatry, 2007, vol. 78, n° 2, p. 187-9. https://archive-ouverte.unige.ch/unige:44603

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Deposited on : 2015-01-07

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