en
Scientific article
Open access
English

Changes in biomarkers after therapeutic intervention in temporal arteries cultured in Matrigel: a new model for preclinical studies in giant-cell arteritis

Published inAnnals of the rheumatic diseases, vol. 73, no. 3, p. 616-623
Publication date2014
Abstract

Search for therapeutic targets in giant-cell arteritis (GCA) is hampered by the scarcity of functional systems. We developed a new model consisting of temporal artery culture in tri-dimensional matrix and assessed changes in biomarkers induced by glucocorticoid treatment.

Keywords
  • Biological Markers/metabolism
  • Collagen
  • Cytokines/biosynthesis/genetics
  • Dexamethasone/pharmacology
  • Drug Combinations
  • Drug Evaluation, Preclinical/methods
  • Gene Expression Regulation/drug effects
  • Giant Cell Arteritis/metabolism/pathology
  • Glucocorticoids/pharmacology
  • Humans
  • Inflammation Mediators/metabolism
  • Laminin
  • Models, Biological
  • Proteoglycans
  • RNA, Messenger/genetics
  • Temporal Arteries/drug effects/metabolism/pathology
  • Tissue Culture Techniques/methods
Citation (ISO format)
CORBERA-BELLALTA, Marc et al. Changes in biomarkers after therapeutic intervention in temporal arteries cultured in Matrigel: a new model for preclinical studies in giant-cell arteritis. In: Annals of the rheumatic diseases, 2014, vol. 73, n° 3, p. 616–623. doi: 10.1136/annrheumdis-2012-202883
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0003-4967
573views
617downloads

Technical informations

Creation12/09/2014 12:06:00 PM
First validation12/09/2014 12:06:00 PM
Update time03/14/2023 10:35:22 PM
Status update03/14/2023 10:35:22 PM
Last indexation08/29/2023 1:58:53 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack