

![]() |
Changes in biomarkers after therapeutic intervention in temporal arteries cultured in Matrigel: a new model for preclinical studies in giant-cell arteritis |
|
Authors | ![]() | |
Published in | Annals of the Rheumatic Diseases. 2014, vol. 73, no. 3, p. 616-23 | |
Abstract | Search for therapeutic targets in giant-cell arteritis (GCA) is hampered by the scarcity of functional systems. We developed a new model consisting of temporal artery culture in tri-dimensional matrix and assessed changes in biomarkers induced by glucocorticoid treatment. | |
Keywords | Biological Markers/metabolism — Collagen — Cytokines/biosynthesis/genetics — Dexamethasone/pharmacology — Drug Combinations — Drug Evaluation, Preclinical/methods — Gene Expression Regulation/drug effects — Giant Cell Arteritis/metabolism/pathology — Glucocorticoids/pharmacology — Humans — Inflammation Mediators/metabolism — Laminin — Models, Biological — Proteoglycans — RNA, Messenger/genetics — Temporal Arteries/drug effects/metabolism/pathology — Tissue Culture Techniques/methods | |
Identifiers | PMID: 23625984 | |
Full text | ||
Structures | ||
Research group | Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779) | |
Citation (ISO format) | CORBERA-BELLALTA, Marc et al. Changes in biomarkers after therapeutic intervention in temporal arteries cultured in Matrigel: a new model for preclinical studies in giant-cell arteritis. In: Annals of the rheumatic diseases, 2014, vol. 73, n° 3, p. 616-23. doi: 10.1136/annrheumdis-2012-202883 https://archive-ouverte.unige.ch/unige:44564 |