Changes in biomarkers after therapeutic intervention in temporal arteries cultured in Matrigel: a new model for preclinical studies in giant-cell arteritis

Corbera-Bellalta, Marc; García-Martínez, Ana; Lozano, Ester; Planas-Rigol, Ester; Tavera-Bahillo, Itziar; Alba, Marco A; Prieto-González, Sergio; Butjosa, Montserrat; Espígol-Frigolé, Georgina; Hernández-Rodríguez, José; Fernández, Pedro L; Roux-Lombard, Pascale; Dayer, Jean-Michel; Rahman, Mahboob U; Cid, Maria C

doi:10.1136/annrheumdis-2012-202883

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Title		Changes in biomarkers after therapeutic intervention in temporal arteries cultured in Matrigel: a new model for preclinical studies in giant-cell arteritis
Authors		Corbera-Bellalta, Marc García-Martínez, Ana Lozano, Ester Planas-Rigol, Ester Tavera-Bahillo, Itziar Alba, Marco A Prieto-González, Sergio Butjosa, Montserrat Espígol-Frigolé, Georgina Hernández-Rodríguez, José Fernández, Pedro L Roux-Lombard, Pascale Dayer, Jean-Michel Rahman, Mahboob U Cid, Maria C show all authors [1 - 15]
Published in		Annals of the Rheumatic Diseases. 2014, vol. 73, no. 3, p. 616-23
Abstract		Search for therapeutic targets in giant-cell arteritis (GCA) is hampered by the scarcity of functional systems. We developed a new model consisting of temporal artery culture in tri-dimensional matrix and assessed changes in biomarkers induced by glucocorticoid treatment.
Keywords		Biological Markers/metabolism — Collagen — Cytokines/biosynthesis/genetics — Dexamethasone/pharmacology — Drug Combinations — Drug Evaluation, Preclinical/methods — Gene Expression Regulation/drug effects — Giant Cell Arteritis/metabolism/pathology — Glucocorticoids/pharmacology — Humans — Inflammation Mediators/metabolism — Laminin — Models, Biological — Proteoglycans — RNA, Messenger/genetics — Temporal Arteries/drug effects/metabolism/pathology — Tissue Culture Techniques/methods
Identifiers		DOI: 10.1136/annrheumdis-2012-202883 PMID: 23625984
Full text		Article (Published version) (3.5 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)
Citation (ISO format)		CORBERA-BELLALTA, Marc et al. Changes in biomarkers after therapeutic intervention in temporal arteries cultured in Matrigel: a new model for preclinical studies in giant-cell arteritis. In: Annals of the rheumatic diseases, 2014, vol. 73, n° 3, p. 616-23. doi: 10.1136/annrheumdis-2012-202883 https://archive-ouverte.unige.ch/unige:44564