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Title

The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study
Authors
Pisetsky, D S
Trace, S E
Brownley, K A
Hamer, R M
Zucker, N L
Roux-Lombard, Pascale
Dayer, Jean-Michel
Bulik, C M
Published in Cytokine. 2014, vol. 69, no. 1, p. 110-5
Abstract Anorexia nervosa (AN) is a serious, potentially life-threatening disorder characterized by severe weight loss, dysregulated eating, and often excessive exercise. While psychiatric illnesses such as depression are associated with increased levels of pro-inflammatory mediators, evidence for such disturbances in patients with AN has been less clear. In an exploratory study of possible disturbances in immune responses in AN, we assayed a panel of cytokines and chemokines in the blood of patients undergoing inpatient treatment, testing the hypothesis that metabolic disturbances in this disease would lead to a pattern of immune disturbances distinct from that of other psychiatric diseases. For this purpose, we evaluated patients by the Beck Depression Inventory-II (BDI-II) and the Eating Disorders Examination-Questionnaire and assessed cytokines and chemokines by enzyme-linked immunosorbent assays. Patients reported a moderate level of depression (mean BDI-II = 22.6) but exhibited few immunologic abnormalities of the kind associated with major depressive disorder [e.g., increased interleukin (IL)-6]; RANTES showed the most frequent elevations and was increased in 4 of the patients studied. Together, these findings suggest that features of AN such as loss of adipose tissue and excessive exercise may attenuate cytokine production and thus modulate the experience of illness that impacts on core features of disease.
Identifiers
PMID: 25022969
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Article (Published version) (270 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Research group Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)
Citation
(ISO format) 		PISETSKY, D S et al. The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study. In: Cytokine, 2014, vol. 69, n° 1, p. 110-5. https://archive-ouverte.unige.ch/unige:44561

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Deposited on : 2015-01-06

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