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Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis

ContributorsParel, Yann; Aurrand-Lions, Michel; Scheja, Agneta; Dayer, Jean-Michel; Roosnek, Eddy Emile; Chizzolini, Carlo
Published inArthritis and rheumatism, vol. 56, no. 10, p. 3459-3467
Publication date2007
Abstract

Fibrotic skin changes in systemic sclerosis (SSc) are preceded by the appearance of an inflammatory infiltrate rich in T cells. Since no direct comparison with T cells in normal skin has been performed previously, this study was undertaken to functionally characterize T cells in the skin of patients with early active SSc and in normal skin.

Keywords
  • Aged
  • Biopsy
  • CD4-Positive T-Lymphocytes/immunology
  • CD8-Positive T-Lymphocytes/immunology
  • Case-Control Studies
  • Female
  • Gene Expression
  • Humans
  • Interleukin-4/biosynthesis
  • Male
  • Middle Aged
  • Scleroderma, Systemic/blood/immunology
  • Skin/pathology
Affiliation entities
Research groups
Citation (ISO format)
PAREL, Yann et al. Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis. In: Arthritis and rheumatism, 2007, vol. 56, n° 10, p. 3459–3467. doi: 10.1002/art.22927
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Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN0004-3591
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507downloads

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