UNIGE document Scientific Article
previous document  unige:44555  next document
add to browser collection
Title

Anti-fibroblast antibodies detected by cell-based ELISA in systemic sclerosis enhance the collagenolytic activity and matrix metalloproteinase-1 production in dermal fibroblasts

Authors
Fineschi, S
Cozzi, F
Dayer, J-M
Meroni, P L
Published in Rheumatology. 2007, vol. 46, no. 12, p. 1779-85
Abstract Antibodies binding to the surface of fibroblasts (anti-fibroblast antibodies: AFA) have been described in systemic sclerosis (SSc). We aimed to assess the effect of AFA on extracellular matrix (ECM) turnover and whether AFA were associated with anti-topoisomerase-I antibody.
Keywords AdultAntibodies, Anti-Idiotypic/analysis/drug effectsBlotting, WesternCase-Control StudiesCells, CulturedCollagen/metabolismEnzyme-Linked Immunosorbent AssayFemaleFibroblasts/drug effects/immunologyFluorescent Antibody Technique, IndirectHumansImmunoglobulin G/pharmacologyInterleukin-1/pharmacologyMaleMatrix Metalloproteinase 1/drug effects/metabolismMiddle AgedRNA, Messenger/analysisScleroderma, Systemic/immunology/physiopathologySkin/pathologyTissue Inhibitor of Metalloproteinase-1/drug effects/metabolism
Identifiers
PMID: 17982166
Full text
Article (Published version) (208 Kb) - public document Free access
Structures
Research group La matrice extracellulaire (651)
Citation
(ISO format)
FINESCHI, S et al. Anti-fibroblast antibodies detected by cell-based ELISA in systemic sclerosis enhance the collagenolytic activity and matrix metalloproteinase-1 production in dermal fibroblasts. In: Rheumatology, 2007, vol. 46, n° 12, p. 1779-85. https://archive-ouverte.unige.ch/unige:44555

116 hits

35 downloads

Update

Deposited on : 2015-01-06

Export document
Format :
Citation style :