en
Scientific article
English

SPECT in periodic lateralized epileptiform discharges (PLEDs): a form of partial status epilepticus?

Published inSeizure, vol. 10, no. 4, p. 260-265
Publication date2001
Abstract

Periodic lateralized epileptiform discharges (PLEDs) are a well defined electroencephalographic entity but whether PLEDs represent an ictal condition or not remains debated. Much work has been done using electroencephalography (EEG) but new approaches using cerebral perfusion imaging may give more information about this question. We aimed to evaluate if PLEDs were associated with high regional cerebral blood flow (rCBF). We studied 18 patients with PLEDs and different pathologies, and performed brain single-photon-emission computed tomography (SPECT) during and, for three cases, after the disappearance of PLEDs. Qualitative variations and locations of rCBF were compared with PLEDs. Association with seizures and type of seizures were also assessed. SPECT showed high rCBF in 18/18 patients (100%). The location of PLEDs and high rCBF matched in 17/18 cases (94%). In the three cases where SPECT was performed after PLEDs disappeared, the high rCBF had cleared (100%). Eighteen cases (100%) presented seizures before recording of PLEDs, mainly motor (partial motor or generalized tonic-clonic). Where there was a decreased rCBF (related to a lesion) there was little relationship to PLEDs and all patients with decreased rCBF had an adjacent increased rCBF. These results confirm preliminary case reports. Hyperperfusion adds further to the argument that PLEDs may be related to a form of partial status epilepticus.

Keywords
  • Aged
  • Aged, 80 and over
  • Brain/blood supply/physiopathology/radionuclide imaging
  • Cerebrovascular Circulation/physiology
  • Electroencephalography
  • Female
  • Functional Laterality/physiology
  • Humans
  • Male
  • Middle Aged
  • Occipital Lobe/blood supply/physiopathology/radionuclide imaging
  • Parietal Lobe/blood supply/physiopathology/radionuclide imaging
  • Periodicity
  • Radiopharmaceuticals/diagnostic use
  • Retrospective Studies
  • Status Epilepticus/diagnosis/physiopathology
  • Technetium Tc 99m Exametazime/diagnostic use
  • Temporal Lobe/blood supply/physiopathology/radionuclide imaging
  • Tomography, Emission-Computed, Single-Photon
Citation (ISO format)
ASSAL, Frédéric et al. SPECT in periodic lateralized epileptiform discharges (PLEDs): a form of partial status epilepticus? In: Seizure, 2001, vol. 10, n° 4, p. 260–265. doi: 10.1053/seiz.2000.0506
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1059-1311
582views
0downloads

Technical informations

Creation12/05/2014 2:55:00 PM
First validation12/05/2014 2:55:00 PM
Update time03/14/2023 10:35:10 PM
Status update03/14/2023 10:35:09 PM
Last indexation01/16/2024 3:35:37 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack