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Ex utero intrapartum treatment (EXIT), a resuscitation option for intra-thoracic foetal pathologies

Peiry, Barbara
Published in Schweizerische medizinische Wochenschrift. 2007, vol. 137, no. 19-20, p. 279-85
Abstract The ex utero intrapartum treatment (EXIT) procedure is designed to guarantee sufficient oxygenation for a foetus at risk of airway obstruction. This is achieved by improving lung ventilation, usually by establishing an airway during caesarean delivery whilst preserving the foetal-placental circulation temporarily. Indications for the EXIT procedure have extended from its original use in reversing iatrogenic tracheal obstruction in congenital diaphragmatic hernia to naturally occurring upper airway obstructions. We report our experience with a new and rarely mentioned indication for the EXIT procedure, intra-thoracic volume expansions. The elaboration of lowest risk scenarios through balancing risks with alternative options, foetal or neonatal intervention and coordination between professionals from various disciplines are the most important conditions for a successful EXIT procedure. The EXIT procedure requires a caesarean section that specifically differs from the traditional caesarean section during which uterine tone is maintained to minimize maternal bleeding. To guarantee foetal oxygenation during the EXIT procedure, profound uterine relaxation is desired. To gain time with optimal placental oxygenation in order to safely perform an airway intervention in a baby at risk of hypoxia may require deep inhalation anaesthesia and/or tocolytic agents. We review the EXIT procedure and present a case series from the University Hospital of Geneva that contrasts with the common indication for the EXIT procedure usually based on upper airway obstruction by its exclusive indication for intra-thoracic malformations/diseases.
Keywords Airway Obstruction/congenital/surgeryAnesthesia, ObstetricalAnesthesia, SpinalBlood CirculationCesarean Section/methodsFemaleFetal Diseases/surgeryFetus/blood supplyHumansInfant, NewbornObstetric Labor Complications/surgeryPregnancyResuscitation/methodsThoracic Diseases/congenital/surgeryUmbilical Cord/blood supplyUterine Contraction/drug effects
PMID: 17594540
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Research group Réanimation néonatale en salle d'accouchement (696)
(ISO format)
KERN, Christian et al. Ex utero intrapartum treatment (EXIT), a resuscitation option for intra-thoracic foetal pathologies. In: Schweizerische medizinische Wochenschrift, 2007, vol. 137, n° 19-20, p. 279-85. https://archive-ouverte.unige.ch/unige:44531

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Deposited on : 2015-01-06

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