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Isotope specific resolution recovery image reconstruction in high resolution PET imaging

Angelis, Georgios I
Anton-Rodriguez, Jose
Matthews, Julian C
Reader, Andrew J
Published in Medical physics. 2014, vol. 41, no. 5, 052503
Abstract Measuring and incorporating a scanner-specific point spread function (PSF) within image reconstruction has been shown to improve spatial resolution in PET. However, due to the short half-life of clinically used isotopes, other long-lived isotopes not used in clinical practice are used to perform the PSF measurements. As such, non-optimal PSF models that do not correspond to those needed for the data to be reconstructed are used within resolution modeling (RM) image reconstruction, usually underestimating the true PSF owing to the difference in positron range. In high resolution brain and preclinical imaging, this effect is of particular importance since the PSFs become more positron range limited and isotope-specific PSFs can help maximize the performance benefit from using resolution recovery image reconstruction algorithms.
Keywords AlgorithmsBrain Neoplasms/radionuclide imagingCarbon Radioisotopes/diagnostic useFeasibility StudiesFluorine Radioisotopes/diagnostic useHead/radionuclide imagingHumansImage Processing, Computer-Assisted/methodsOligodendroglioma/radionuclide imagingPhantoms, ImagingPositron-Emission Tomography/instrumentation/methodsRadiopharmaceuticals/diagnostic use
PMID: 24784400
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Article (Published version) (1.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Imagerie Médicale (TEP et TEMP) (542)
Swiss National Science Foundation: 31003A_149957
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KOTASIDIS, Fotis et al. Isotope specific resolution recovery image reconstruction in high resolution PET imaging. In: Medical physics, 2014, vol. 41, n° 5, p. 052503. doi: 10.1118/1.4870985 https://archive-ouverte.unige.ch/unige:44517

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Deposited on : 2015-01-06

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