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Scientific article
English

Evaluation of radiation dose to anthropomorphic paediatric models from positron-emitting labelled tracers

Published inPhysics in medicine and biology, vol. 59, no. 5, p. 1165-1187
Publication date2014
Abstract

PET uses specific molecules labelled with positron-emitting radionuclides to provide valuable biochemical and physiological information. However, the administration of radiotracers to patients exposes them to low-dose ionizing radiation, which is a concern in the paediatric population since children are at a higher cancer risk from radiation exposure than adults. Therefore, radiation dosimety calculations for commonly used positron-emitting radiotracers in the paediatric population are highly desired. We evaluate the absorbed dose and effective dose for 19 positron-emitting labelled radiotracers in anthropomorphic paediatric models including the newborn, 1-, 5-, 10- and 15-year-old male and female. This is achieved using pre-calculated S-values of positron-emitting radionuclides of UF-NCI paediatric phantoms and published biokinetic data for various radiotracers. The influence of the type of anthropomorphic model, tissue weight factors and direct human- versus mouse-derived biokinetic data on the effective dose for paediatric phantoms was also evaluated. In the case of (18)F-FDG, dosimetry calculations of reference paediatric patients from various dose regimens were also calculated. Among the considered radiotracers, (18)F-FBPA and (15)O-water resulted in the highest and lowest effective dose in the paediatric phantoms, respectively. The ICRP 103 updated tissue-weighting factors decrease the effective dose in most cases. Substantial differences of radiation dose were observed between direct human- versus mouse-derived biokinetic data. Moreover, the effect of using voxel- versus MIRD-type models on the calculation of the effective dose was also studied. The generated database of absorbed organ dose and effective dose for various positron-emitting labelled radiotracers using new generation computational models and the new ICRP tissue-weighting factors can be used for the assessment of radiation risks to paediatric patients in clinical practice. This work also contributes to a better understanding of the factors influencing patient-specific radiation dose calculation.

Keywords
  • Adolescent
  • Aging/physiology
  • Biomimetic Materials
  • Child
  • Child, Preschool
  • Computer Simulation
  • Electrons
  • Female
  • Humans
  • Infant
  • Isotope Labeling
  • Male
  • Models, Biological
  • Organ Specificity
  • Phantoms, Imaging
  • Positron-Emission Tomography/instrumentation/methods
  • Radiation Dosage
  • Radioactive Tracers
  • Radioisotopes/analysis/diagnostic use
  • Whole-Body Counting/methods
Citation (ISO format)
XIE, Tianwu, ZAIDI, Habib. Evaluation of radiation dose to anthropomorphic paediatric models from positron-emitting labelled tracers. In: Physics in medicine and biology, 2014, vol. 59, n° 5, p. 1165–1187. doi: 10.1088/0031-9155/59/5/1165
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Article (Published version)
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Identifiers
ISSN of the journal0031-9155
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