UNIGE document Scientific Article
previous document  unige:44445  next document
add to browser collection

Evaluation of radiation dose to anthropomorphic paediatric models from positron-emitting labelled tracers

Published in Physics in Medicine and Biology. 2014, vol. 59, no. 5, p. 1165-87
Abstract PET uses specific molecules labelled with positron-emitting radionuclides to provide valuable biochemical and physiological information. However, the administration of radiotracers to patients exposes them to low-dose ionizing radiation, which is a concern in the paediatric population since children are at a higher cancer risk from radiation exposure than adults. Therefore, radiation dosimety calculations for commonly used positron-emitting radiotracers in the paediatric population are highly desired. We evaluate the absorbed dose and effective dose for 19 positron-emitting labelled radiotracers in anthropomorphic paediatric models including the newborn, 1-, 5-, 10- and 15-year-old male and female. This is achieved using pre-calculated S-values of positron-emitting radionuclides of UF-NCI paediatric phantoms and published biokinetic data for various radiotracers. The influence of the type of anthropomorphic model, tissue weight factors and direct human- versus mouse-derived biokinetic data on the effective dose for paediatric phantoms was also evaluated. In the case of (18)F-FDG, dosimetry calculations of reference paediatric patients from various dose regimens were also calculated. Among the considered radiotracers, (18)F-FBPA and (15)O-water resulted in the highest and lowest effective dose in the paediatric phantoms, respectively. The ICRP 103 updated tissue-weighting factors decrease the effective dose in most cases. Substantial differences of radiation dose were observed between direct human- versus mouse-derived biokinetic data. Moreover, the effect of using voxel- versus MIRD-type models on the calculation of the effective dose was also studied. The generated database of absorbed organ dose and effective dose for various positron-emitting labelled radiotracers using new generation computational models and the new ICRP tissue-weighting factors can be used for the assessment of radiation risks to paediatric patients in clinical practice. This work also contributes to a better understanding of the factors influencing patient-specific radiation dose calculation.
Keywords AdolescentAging/physiologyBiomimetic MaterialsChildChild, PreschoolComputer SimulationElectronsFemaleHumansInfantIsotope LabelingMaleModels, BiologicalOrgan SpecificityPhantoms, ImagingPositron-Emission Tomography/instrumentation/methodsRadiation DosageRadioactive TracersRadioisotopes/analysis/diagnostic useWhole-Body Counting/methods
PMID: 24557029
Full text
Article (Published version) (2.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Imagerie Médicale (TEP et TEMP) (542)
(ISO format)
XIE, Tianwu, ZAIDI, Habib. Evaluation of radiation dose to anthropomorphic paediatric models from positron-emitting labelled tracers. In: Physics in Medicine and Biology, 2014, vol. 59, n° 5, p. 1165-87. https://archive-ouverte.unige.ch/unige:44445

159 hits

0 download


Deposited on : 2015-01-05

Export document
Format :
Citation style :