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Growth factors and plasticity

Bednarek, Nathalie
Gressens, Pierre
Published in Seminars in fetal & neonatal medicine. 2007, vol. 12, no. 4, p. 241-9
Abstract Neuroprotective strategies can prevent lesions from getting worse but agents that have neurotrophic properties can also affect repair in a developing brain. Although prevention and treatment in the early stages of brain lesions are desirable, delayed cell death or improved post-lesion plasticity are the only realistic targets in many cases. Several trophic factors can limit delayed cell death in animal models of perinatal brain damage. In addition, melatonin and brain-derived neurotrophic factor have been shown to promote post-lesion plasticity following neonatal excitotoxic white-matter damage in newborn mice. Despite these promising results, additional preclinical data are required for most of the trophic factors that have been tested, although some candidate drugs, e.g. melatonin or erythropoietin, might reach clinical trials in the near future.
Keywords AnimalsAnimals, NewbornBrain/drug effects/physiologyClinical Trials as TopicErythropoietin/pharmacologyHumansIntercellular Signaling Peptides and Proteins/pharmacologyMelatonin/pharmacologyMiceNeuronal Plasticity/drug effectsNeuroprotective Agents/pharmacology
PMID: 17336172
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SIZONENKO, Stéphane, BEDNAREK, Nathalie, GRESSENS, Pierre. Growth factors and plasticity. In: Seminars in fetal & neonatal medicine, 2007, vol. 12, n° 4, p. 241-9. doi: 10.1016/j.siny.2007.01.007 https://archive-ouverte.unige.ch/unige:44393

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Deposited on : 2015-01-05

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