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Spacers entre prostate et rectum : optimisation des techniques d'irradiation du cancer de la prostate [Prostate-rectum spacers: optimization of prostate cancer irradiation]

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Published in Cancer Radiothérapie. 2014, vol. 18, no. 3, p. 215-21;quiz243-4,247
Abstract In the curative radiotherapy of localized prostate cancer, improvements in biochemical control observed with dose escalation have been counterbalanced by an increase in radiation-induced toxicity. The injection of biodegradable spacers between prostate and rectum represents a new frontier in the optimization of radiotherapy treatments for patients with localized disease. Transperineal injection of different types of spacers under transrectal ultrasound guidance allows creating a 7-to-20 mm additional space between the prostate and the anterior rectal wall lasting 3 to 12 months. Dosimetrically, a relative reduction in the rectal volume receiving at least 70 Gy (V70) in the order of 43% to 84% is observed with all types of spacers, regardless of the radiotherapy technique used. Preliminary clinical results show for all spacers a good tolerance and a possible reduction in the acute side effects rate. The aim of the present systematic review of the literature is to report on indications as well as dosimetric and clinical advantages of the different types of prostate-rectum spacers commercially available (hydrogel, hyaluronic acid, collagen, biodegradable balloon).
Keywords Absorbable ImplantsBrachytherapyClinical Trials as TopicCollagenHumansHyaluronic AcidMaleOrgans at Risk/radiation effectsPolyethylene GlycolsProstatic Neoplasms/radiotherapyRadiation Injuries/prevention & controlRadiation Protection/instrumentationRadiotherapy DosageRectum/radiation effects
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PMID: 24746454
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Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Article (Published version) (158 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Article (Published version) (147 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Groupe Miralbell Raymond (radio-oncologie) (685)
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ZILLI, Thomas, BENZ, Eileen, MIRALBELL, Raymond. Spacers entre prostate et rectum : optimisation des techniques d'irradiation du cancer de la prostate [Prostate-rectum spacers: optimization of prostate cancer irradiation]. In: Cancer Radiothérapie, 2014, vol. 18, n° 3, p. 215-21;quiz243-4,247. doi: 10.1016/j.canrad.2014.03.001 https://archive-ouverte.unige.ch/unige:44384

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Deposited on : 2015-01-05

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