en
Scientific article
Review
French

Spacers entre prostate et rectum : optimisation des techniques d'irradiation du cancer de la prostate [Prostate-rectum spacers: optimization of prostate cancer irradiation]

Published inCancer radiothérapie, vol. 18, no. 3, p. 215-221;quiz243-4,247
Publication date2014
Abstract

In the curative radiotherapy of localized prostate cancer, improvements in biochemical control observed with dose escalation have been counterbalanced by an increase in radiation-induced toxicity. The injection of biodegradable spacers between prostate and rectum represents a new frontier in the optimization of radiotherapy treatments for patients with localized disease. Transperineal injection of different types of spacers under transrectal ultrasound guidance allows creating a 7-to-20 mm additional space between the prostate and the anterior rectal wall lasting 3 to 12 months. Dosimetrically, a relative reduction in the rectal volume receiving at least 70 Gy (V70) in the order of 43% to 84% is observed with all types of spacers, regardless of the radiotherapy technique used. Preliminary clinical results show for all spacers a good tolerance and a possible reduction in the acute side effects rate. The aim of the present systematic review of the literature is to report on indications as well as dosimetric and clinical advantages of the different types of prostate-rectum spacers commercially available (hydrogel, hyaluronic acid, collagen, biodegradable balloon).

Keywords
  • Absorbable Implants
  • Brachytherapy
  • Clinical Trials as Topic
  • Collagen
  • Humans
  • Hyaluronic Acid
  • Male
  • Organs at Risk/radiation effects
  • Polyethylene Glycols
  • Prostatic Neoplasms/radiotherapy
  • Radiation Injuries/prevention & control
  • Radiation Protection/instrumentation
  • Radiotherapy Dosage
  • Rectum/radiation effects
Citation (ISO format)
ZILLI, Thomas, BENZ, Eileen, MIRALBELL, Raymond. Spacers entre prostate et rectum : optimisation des techniques d’irradiation du cancer de la prostate [Prostate-rectum spacers: optimization of prostate cancer irradiation]. In: Cancer radiothérapie, 2014, vol. 18, n° 3, p. 215–221;quiz243–4,247. doi: 10.1016/j.canrad.2014.03.001
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Identifiers
ISSN of the journal1278-3218
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Technical informations

Creation12/23/2014 10:02:00 AM
First validation12/23/2014 10:02:00 AM
Update time03/14/2023 10:34:00 PM
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