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Title

Risk factors for ICU admission and ICU survival after allogeneic hematopoietic SCT.

Authors
Benz, R
Schanz, U
Maggiorini, M
Stussi, G
Published in Bone Marrow Transplantation. 2014, vol. 49, no. 1, p. 62-5
Abstract A considerable number of patients undergoing allogeneic hematopoietic SCT (HSCT) develop post-transplant complications requiring intensive care unit (ICU) treatment. Whereas the indications and the outcome of ICU admission are well known, the risk factors leading to ICU admission are less well understood. We performed a retrospective single-center study on 250 consecutive HSCT patients analyzing the indications, risk factors and outcome of ICU admission. Of these 250 patients, 33 (13%) were admitted to the ICU. The most common indications for admission to the ICU were pulmonary complications (11, 33%), sepsis (8, 24%), neurological disorders (6, 18%) and cardiovascular problems (2, 6%). Acute GvHD and HLA mismatch were the only significant risk factors for ICU admission in multivariate analysis. Among patients admitted to the ICU, the number of organ failures correlated negatively with survival. Twenty-one (64%) patients died during the ICU stay and the 6-month mortality was 85% (27 out of 33). SAPS II score underestimated the mortality rate. In conclusion, acute GvHD and HLA mismatch were identified as risk factors for ICU admission following allogeneic HSCT. Both, short- and long-term survival of patients admitted to the ICU remains dismal and depends on the number of organ failures.
Keywords AdolescentAdultAgedDisease ProgressionFemaleHematopoietic Stem Cell Transplantation/adverse effects/methodsHumansIntensive Care/methodsIntensive Care Units/statistics & numerical dataLeukemia/mortality/therapyLymphoma/mortality/therapyMaleMiddle AgedRecurrenceRespiration Disorders/etiology/mortalityRetrospective StudiesRisk FactorsSepsis/etiology/mortalitySwitzerlandTransplantation ConditioningTransplantation, HomologousTreatment OutcomeYoung Adult
Identifiers
PMID: 24056739
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Article (Published version) (260 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
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BENZ, R et al. Risk factors for ICU admission and ICU survival after allogeneic hematopoietic SCT. In: Bone Marrow Transplantation, 2014, vol. 49, n° 1, p. 62-5. https://archive-ouverte.unige.ch/unige:44293

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Deposited on : 2014-12-23

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