Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood

Bongoni, Anjan K; Kiermeir, David; Jenni, Hansjörg; Bähr, Andrea; Ayares, David; Klymiuk, Nikolai; Wolf, Eckhard; Voegelin, Esther; Constantinescu, Mihai A; Seebach, Jorg Dieter; Rieben, Robert

doi:10.1111/xen.12090

Scientific article

English

Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood

ContributorsBongoni, Anjan K; Kiermeir, David; Jenni, Hansjörg; Bähr, Andrea; Ayares, David; Klymiuk, Nikolai; Wolf, Eckhard; Voegelin, Esther; Constantinescu, Mihai A; Seebach, Jorg Dieter; Rieben, Robert

Published inXenotransplantation, vol. 21, no. 3, p. 230-243

Publication date2014

Abstract

Besides α1,3-galactosyltransferase gene (GGTA1) knockout, several transgene combinations to prevent pig-to-human xenograft rejection are currently being investigated. In this study, the potential of combined overexpression of human CD46 and HLA-E to prevent complement- and NK-cell-mediated xenograft rejection was tested in an ex vivo pig-to-human xenoperfusion model.

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

Laboratoire d'immunologie translationnelle (856)

Citation (ISO format)

BONGONI, Anjan K et al. Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood. In: Xenotransplantation, 2014, vol. 21, n° 3, p. 230–243. doi: 10.1111/xen.12090

Article (Published version)

Identifiers

PID : unige:44284
DOI : 10.1111/xen.12090
PMID : 24635052

ISSN of the journal0908-665X

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Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood

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