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Scientific article
English

Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood

ContributorsBongoni, Anjan K; Kiermeir, David; Jenni, Hansjörg; Bähr, Andrea; Ayares, David; Klymiuk, Nikolai; Wolf, Eckhard; Voegelin, Esther; Constantinescu, Mihai A; Seebach, Jorg Dieter; Rieben, Robert
Published inXenotransplantation, vol. 21, no. 3, p. 230-243
Publication date2014
Abstract

Besides α1,3-galactosyltransferase gene (GGTA1) knockout, several transgene combinations to prevent pig-to-human xenograft rejection are currently being investigated. In this study, the potential of combined overexpression of human CD46 and HLA-E to prevent complement- and NK-cell-mediated xenograft rejection was tested in an ex vivo pig-to-human xenoperfusion model.

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BONGONI, Anjan K et al. Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood. In: Xenotransplantation, 2014, vol. 21, n° 3, p. 230–243. doi: 10.1111/xen.12090
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accessLevelRestricted
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Journal ISSN0908-665X
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Creation15/12/2014 15:50:00
First validation15/12/2014 15:50:00
Update09/01/2025 10:31:06
Status update09/01/2025 10:31:06
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