A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

Czikora, István; Alli, Abdel; Bao, Hui-Fang; Kaftan, David; Sridhar, Supriya; Apell, Hans-Jürgen; Gorshkov, Boris; White, Richard; Zimmermann, Astrid; Wendel, Albrecht; Pauly-Evers, Meike; Hamacher, Jurg; Garcia, Irène; Fischer, Bernhard; Verin, Alexander; Bagi, Zsolt; Pittet, Jean Francois; Shabbir, Waheed; Lemmens-Gruber, Rosa; Chakraborty, Trinad; Lazrak, Ahmed; Matthay, Michael A; Eaton, Douglas C; Lucas, Rudolf

doi:10.1164/rccm.201405-0833OC

Professional article

English

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

Published inAmerican journal of respiratory and critical care medicine, vol. 190, no. 5, p. 522-532

Publication date2014

Abstract

Alveolar liquid clearance is regulated by Na(+) uptake through the apically expressed epithelial sodium channel (ENaC) and basolaterally localized Na(+)-K(+)-ATPase in type II alveolar epithelial cells. Dysfunction of these Na(+) transporters during pulmonary inflammation can contribute to pulmonary edema.

Keywords

Animals
Bacterial Proteins
Epithelial Sodium Channel Agonists/chemistry/metabolism
Epithelial Sodium Channels/chemistry/metabolism
Female
Male
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Peptides, Cyclic/chemistry/metabolism
Pulmonary Alveoli/metabolism/microbiology
Pulmonary Edema/metabolism/microbiology
Streptolysins
Tumor Necrosis Factor-alpha/chemistry/metabolism

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research groups

Rôles des cytokines de la famille du TNF dans les infections mycobactériennes (500)

Citation (ISO format)

CZIKORA, István et al. A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation. In: American journal of respiratory and critical care medicine, 2014, vol. 190, n° 5, p. 522–532. doi: 10.1164/rccm.201405-0833OC

Article (Published version)

Identifiers

PID : unige:44198
DOI : 10.1164/rccm.201405-0833OC
PMID : 25029038

Journal ISSN1073-449X

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Creation25/11/2014 16:55:00

First validation25/11/2014 16:55:00

Update14/03/2023 22:32:47

Status update14/03/2023 22:32:46

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A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

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