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Title

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

Authors
Czikora, István
Alli, Abdel
Bao, Hui-Fang
Kaftan, David
Sridhar, Supriya
Apell, Hans-Jürgen
Gorshkov, Boris
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Published in American Journal of Respiratory and Critical Care Medicine. 2014, vol. 190, no. 5, p. 522-32
Abstract Alveolar liquid clearance is regulated by Na(+) uptake through the apically expressed epithelial sodium channel (ENaC) and basolaterally localized Na(+)-K(+)-ATPase in type II alveolar epithelial cells. Dysfunction of these Na(+) transporters during pulmonary inflammation can contribute to pulmonary edema.
Keywords AnimalsBacterial ProteinsEpithelial Sodium Channel Agonists/chemistry/metabolismEpithelial Sodium Channels/chemistry/metabolismFemaleMaleMiceMice, Inbred C57BLMice, Mutant StrainsPeptides, Cyclic/chemistry/metabolismPulmonary Alveoli/metabolism/microbiologyPulmonary Edema/metabolism/microbiologyStreptolysinsTumor Necrosis Factor-alpha/chemistry/metabolism
Identifiers
PMID: 25029038
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Article (Published version) (1.2 MB) - public document Free access
Structures
Research group Rôles des cytokines de la famille du TNF dans les infections mycobactériennes (500)
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CZIKORA, István et al. A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation. In: American Journal of Respiratory and Critical Care Medicine, 2014, vol. 190, n° 5, p. 522-32. https://archive-ouverte.unige.ch/unige:44198

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Deposited on : 2014-12-23

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