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A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

Published inAmerican journal of respiratory and critical care medicine, vol. 190, no. 5, p. 522-532
Publication date2014
Abstract

Alveolar liquid clearance is regulated by Na(+) uptake through the apically expressed epithelial sodium channel (ENaC) and basolaterally localized Na(+)-K(+)-ATPase in type II alveolar epithelial cells. Dysfunction of these Na(+) transporters during pulmonary inflammation can contribute to pulmonary edema.

Keywords
  • Animals
  • Bacterial Proteins
  • Epithelial Sodium Channel Agonists/chemistry/metabolism
  • Epithelial Sodium Channels/chemistry/metabolism
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Peptides, Cyclic/chemistry/metabolism
  • Pulmonary Alveoli/metabolism/microbiology
  • Pulmonary Edema/metabolism/microbiology
  • Streptolysins
  • Tumor Necrosis Factor-alpha/chemistry/metabolism
Citation (ISO format)
CZIKORA, István et al. A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation. In: American journal of respiratory and critical care medicine, 2014, vol. 190, n° 5, p. 522–532. doi: 10.1164/rccm.201405-0833OC
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1073-449X
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499downloads

Technical informations

Creation11/25/2014 4:55:00 PM
First validation11/25/2014 4:55:00 PM
Update time03/14/2023 10:32:47 PM
Status update03/14/2023 10:32:46 PM
Last indexation01/16/2024 3:28:53 PM
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