Patients reporting unilateral nasal symptoms (epistaxis, new-onset discharge and progressive obstruction), unexplained maxillary pain or hypoaesthesia should be referred to an otolaryngologist for nasal endoscopy. In most cases, biopsies of suspect lesions of the oral and nasal cavity are easy to perform, even on an outpatient basis; being essential for accurate diagnosis and an appropriate treatment, it is important to realise them in a timely fashion. Plasmablastic lymphoma is a rare B-cell lymphoma with poor prognosis, most frequently occurring in the oral cavity and mainly affecting immunocompromised patients.