NF-κB is activated from endosomal compartments in antiphospholipid antibodies-treated human monocytes

Brandt, Karim; Fickentscher, Céline; Boehlen, Françoise; Kruithof, Egbert; De Moerloose, Philippe

doi:10.1111/jth.12536

Professional article

English

NF-κB is activated from endosomal compartments in antiphospholipid antibodies-treated human monocytes

ContributorsBrandt, Karim; Fickentscher, Céline; Boehlen, Françoise; Kruithof, Egbert; De Moerloose, Philippe

Published inJournal of thrombosis and haemostasis, vol. 12, no. 5, p. 779-791

Publication date2014

Abstract

The antiphospholipid antibody syndrome (APS) is an autoimmune disease associated with arterial or venous thrombosis and/or recurrent fetal loss and is caused by pathogenic antiphospholipid antibodies (aPLA). We recently demonstrated that Toll-like receptor 2 (TLR2) and CD14 contribute to monocyte activation of aPLA.

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Citation (ISO format)

BRANDT, Karim et al. NF-κB is activated from endosomal compartments in antiphospholipid antibodies-treated human monocytes. In: Journal of thrombosis and haemostasis, 2014, vol. 12, n° 5, p. 779–791. doi: 10.1111/jth.12536

Article (Published version)

Identifiers

PID : unige:44083
DOI : 10.1111/jth.12536
PMID : 24612386

Journal ISSN1538-7836

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NF-κB is activated from endosomal compartments in antiphospholipid antibodies-treated human monocytes

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