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Title

The effect of simultaneous CD154 and LFA-1 blockade on the survival of allogeneic islet grafts in nonobese diabetic mice

Authors
Pileggi, Antonello
Molano, R Damaris
Poggioli, Raffaella
Zahr, Elsie
Ricordi, Camillo
Inverardi, Luca
Published in Transplantation. 2003, vol. 76, no. 12, p. 1669-74
Abstract The rate of success in clinical transplantation of islets of Langerhans has dramatically improved with perspectives of wide-scale applicability for patients with type 1 diabetes. One drawback is the need for lifelong immunosuppression, which is associated with significant side effects. Immunomodulatory strategies devoid of side effects and with tolerogenic potential, such as co-stimulatory blockade, would be a great improvement if successful. In this study, the authors have explored the effect of simultaneous blockade of CD40/CD154 and intercellular adhesion molecule (ICAM)/lymphocyte function-associated antigen (LFA)-1 interactions.
Keywords AnimalsAntibodies, Monoclonal/therapeutic useBlood Glucose/metabolismCD40 Ligand/immunologyDiabetes Mellitus, Type 1/genetics/surgeryDisease Models, AnimalGraft Survival/drug effects/immunologyImmunosuppressive Agents/therapeutic useIslets of Langerhans Transplantation/immunology/methodsLymphocyte Function-Associated Antigen-1/immunologyMiceMice, Inbred C57BLMice, Inbred NODTransplantation, Homologous/immunology
Identifiers
PMID: 14688513
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Article (Published version) (473 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group La transplantation d'îlots de Langerhans (623)
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(ISO format)
BERNEY, Thierry et al. The effect of simultaneous CD154 and LFA-1 blockade on the survival of allogeneic islet grafts in nonobese diabetic mice. In: Transplantation, 2003, vol. 76, n° 12, p. 1669-74. https://archive-ouverte.unige.ch/unige:43978

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Deposited on : 2014-12-19

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