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Scientific Article - Review
unige:43956 
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Targeting the epithelial cells in fibrosis: a new concept for an old disease |
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| Authors | ||
| Published in | Drug discovery today. 2013, vol. 18, no. 11-12, p. 582-91 | |
| Abstract | Fibrosis, which affects millions of individuals worldwide, is a leading cause of organ failure. For 40 years myofibroblasts have been recognized to be the key cellular players in fibrosis. Currently, several pharmaceutical targets are under investigation that may contribute to the activation of myofibroblasts. Recent preclinical and clinical evidence suggests that other components in the fibrotic microenvironment can trigger myofibroblast activation, providing new targets for pharmaceutical intervention. Epithelial cells may represent the most promising cellular phenotype that could be exploited in the design of new anti-fibrotic medicines through their paracrine action on myofibroblasts. The present review briefly highlights this hypothesis and discusses some interesting related pharmacological targets. | |
| Keywords | Animals — Epithelial Cells/metabolism — Fibrosis/drug therapy/metabolism/pathology — Humans — Myofibroblasts/pathology | |
| Identifiers | PMID: 23348679 | |
| Full text | ||
| Structures | ||
| Research group | Analyse protéomique et Analyse génomique des maladies rénales (659) | |
| Citation (ISO format) | MOLL, Solange et al. Targeting the epithelial cells in fibrosis: a new concept for an old disease. In: Drug discovery today, 2013, vol. 18, n° 11-12, p. 582-91. doi: 10.1016/j.drudis.2013.01.006 https://archive-ouverte.unige.ch/unige:43956 |
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