en
Scientific article
Review
English

Targeting the epithelial cells in fibrosis: a new concept for an old disease

Published inDrug discovery today, vol. 18, no. 11-12, p. 582-591
Publication date2013
Abstract

Fibrosis, which affects millions of individuals worldwide, is a leading cause of organ failure. For 40 years myofibroblasts have been recognized to be the key cellular players in fibrosis. Currently, several pharmaceutical targets are under investigation that may contribute to the activation of myofibroblasts. Recent preclinical and clinical evidence suggests that other components in the fibrotic microenvironment can trigger myofibroblast activation, providing new targets for pharmaceutical intervention. Epithelial cells may represent the most promising cellular phenotype that could be exploited in the design of new anti-fibrotic medicines through their paracrine action on myofibroblasts. The present review briefly highlights this hypothesis and discusses some interesting related pharmacological targets.

Keywords
  • Animals
  • Epithelial Cells/metabolism
  • Fibrosis/drug therapy/metabolism/pathology
  • Humans
  • Myofibroblasts/pathology
Citation (ISO format)
MOLL, Solange et al. Targeting the epithelial cells in fibrosis: a new concept for an old disease. In: Drug discovery today, 2013, vol. 18, n° 11-12, p. 582–591. doi: 10.1016/j.drudis.2013.01.006
Main files (1)
Article (Accepted version)
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Identifiers
ISSN of the journal1359-6446
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