UNIGE document Scientific Article - Review
previous document  unige:43956  next document
add to browser collection

Targeting the epithelial cells in fibrosis: a new concept for an old disease

Chaykovska, Lyubov
Meier, Matthias
Budd, David C
Formentini, Ivan
Pomposiello, Silvia
Published in Drug discovery today. 2013, vol. 18, no. 11-12, p. 582-91
Abstract Fibrosis, which affects millions of individuals worldwide, is a leading cause of organ failure. For 40 years myofibroblasts have been recognized to be the key cellular players in fibrosis. Currently, several pharmaceutical targets are under investigation that may contribute to the activation of myofibroblasts. Recent preclinical and clinical evidence suggests that other components in the fibrotic microenvironment can trigger myofibroblast activation, providing new targets for pharmaceutical intervention. Epithelial cells may represent the most promising cellular phenotype that could be exploited in the design of new anti-fibrotic medicines through their paracrine action on myofibroblasts. The present review briefly highlights this hypothesis and discusses some interesting related pharmacological targets.
Keywords AnimalsEpithelial Cells/metabolismFibrosis/drug therapy/metabolism/pathologyHumansMyofibroblasts/pathology
PMID: 23348679
Full text
Article (Accepted version) (1.8 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Analyse protéomique et Analyse génomique des maladies rénales (659)
(ISO format)
MOLL, Solange et al. Targeting the epithelial cells in fibrosis: a new concept for an old disease. In: Drug discovery today, 2013, vol. 18, n° 11-12, p. 582-91. doi: 10.1016/j.drudis.2013.01.006 https://archive-ouverte.unige.ch/unige:43956

501 hits

0 download


Deposited on : 2014-12-19

Export document
Format :
Citation style :