Lymphocytic leiomyositis and myenteric ganglionitis are intrinsic features of cystic fibrosis: studies in distal intestinal obstruction syndrome and meconium ileus

Smith, Virpi V; Tempia-Caliera Schaeppi, Michela; Bisset, W Michael; Kiparissi, Fevronia; Jaffe, Adam; Milla, Peter J; Lindley, Keith J

doi:10.1097/MPG.0b013e318186d35a

Scientific article

English

Lymphocytic leiomyositis and myenteric ganglionitis are intrinsic features of cystic fibrosis: studies in distal intestinal obstruction syndrome and meconium ileus

ContributorsSmith, Virpi V; Tempia-Caliera Schaeppi, Michela; Bisset, W Michael; Kiparissi, Fevronia; Jaffe, Adam; Milla, Peter J; Lindley, Keith J

Published inJournal of pediatric gastroenterology and nutrition, vol. 49, no. 1, p. 42-51

Publication date2009

Abstract

Cystic fibrosis (CF) is a multisystem disorder intrinsically associated with inflammation of mucosal surfaces. Because inflammation can result in enteric neuromuscular dysfunction we hypothesized that terminal ileitis in patients with CF may predispose to distal ileal obstruction syndrome (DIOS).

Keywords

Adolescent
Child
Child, Preschool
Crohn Disease/complications/physiopathology
Cystic Fibrosis/complications/physiopathology
Duodenum/physiopathology
Female
Fibroblasts/pathology
Ganglion Cysts/physiopathology
Humans
Ileum/physiopathology
Ileus/complications
Infant
Inflammation/etiology/physiopathology
Intestinal Atresia/complications
Intestinal Mucosa/physiopathology
Intestinal Pseudo-Obstruction/etiology/physiopathology
Lymphocytes
Male
Manometry
Meconium
Muscle Cells/metabolism/pathology
Myenteric Plexus/physiopathology
Retrospective Studies

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

Gastroentérologie et transplantation (pédiatrie) (181)

Citation (ISO format)

SMITH, Virpi V et al. Lymphocytic leiomyositis and myenteric ganglionitis are intrinsic features of cystic fibrosis: studies in distal intestinal obstruction syndrome and meconium ileus. In: Journal of pediatric gastroenterology and nutrition, 2009, vol. 49, n° 1, p. 42–51. doi: 10.1097/MPG.0b013e318186d35a

Article (Published version)

Identifiers

PID : unige:43940
DOI : 10.1097/MPG.0b013e318186d35a
PMID : 19710558

Journal ISSN0277-2116

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Lymphocytic leiomyositis and myenteric ganglionitis are intrinsic features of cystic fibrosis: studies in distal intestinal obstruction syndrome and meconium ileus

Cystic fibrosis (CF) is a multisystem disorder intrinsically associated with inflammation of mucosal surfaces. Because inflammation can result in enteric neuromuscular dysfunction we hypothesized that terminal ileitis in patients with CF may predispose to distal ileal obstruction syndrome (DIOS).

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