Scientific article
Case report
Open access

Progressive Crossed-Apraxia of Speech as a First Manifestation of a Probable Corticobasal Degeneration

Published inBehavioural neurology, vol. 25, no. 4, p. 285-289
Publication date2012

We present the longitudinal neurolinguistic, neuropsychological and neurologic follow-up of a 64 y.o. right-handed woman, who developed progressive apraxia of speech (PAOS), followed by peripheral agraphia then a left corticobasal syndrome (CBS). Neuroimaging (CT, MRI and FDG-PET) unequivocally showed progressive right hemispheric atrophy and hypometabolism. This particular evolution first confirms that PAOS is a phenotype of probable corticobasal degeneration (CBD). More importantly, this case underpins the neural organisation of motor planning processing in relation with speech, as well as graphic and limb praxis impairments, and constitutes a rare example of crossed-PAOS.

  • Aged
  • Agraphia/etiology/psychology
  • Basal Ganglia/pathology
  • Basal Ganglia Diseases/complications/pathology/psychology
  • Cerebral Cortex/pathology
  • Disease Progression
  • Female
  • Functional Laterality/physiology
  • Handwriting
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Neurodegenerative Diseases/complications/pathology/psychology
  • Neuropsychological Tests
  • Positron-Emission Tomography
  • Psychomotor Performance/physiology
  • Speech Disorders/etiology/pathology/psychology
  • Tomography, X-Ray Computed
Citation (ISO format)
ASSAL, Frédéric et al. Progressive Crossed-Apraxia of Speech as a First Manifestation of a Probable Corticobasal Degeneration. In: Behavioural neurology, 2012, vol. 25, n° 4, p. 285–289. doi: 10.3233/BEN-2012-110219
Main files (1)
Article (Published version)
ISSN of the journal0953-4180

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