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Progressive Crossed-Apraxia of Speech as a First Manifestation of a Probable Corticobasal Degeneration

Remund, Corinne Dubois
Published in Behavioural neurology. 2012, vol. 25, no. 4, p. 285-289
Abstract We present the longitudinal neurolinguistic, neuropsychological and neurologic follow-up of a 64 y.o. right-handed woman, who developed progressive apraxia of speech (PAOS), followed by peripheral agraphia then a left corticobasal syndrome (CBS). Neuroimaging (CT, MRI and FDG-PET) unequivocally showed progressive right hemispheric atrophy and hypometabolism. This particular evolution first confirms that PAOS is a phenotype of probable corticobasal degeneration (CBD). More importantly, this case underpins the neural organisation of motor planning processing in relation with speech, as well as graphic and limb praxis impairments, and constitutes a rare example of crossed-PAOS.
Keywords AgedAgraphia/etiology/psychologyBasal Ganglia/pathologyBasal Ganglia Diseases/complications/pathology/psychologyCerebral Cortex/pathologyDisease ProgressionFemaleFunctional Laterality/physiologyHandwritingHumansMagnetic Resonance ImagingMiddle AgedNeurodegenerative Diseases/complications/pathology/psychologyNeuropsychological TestsPositron-Emission TomographyPsychomotor Performance/physiologySpeech Disorders/etiology/pathology/psychologyTomography, X-Ray Computed
PMID: 22885809
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Article (Published version) (1.6 MB) - public document Free access
Research groups Neuropsychologie et neurologie comportementale (951)
Perception et production de la parole
(ISO format)
ASSAL, Frédéric et al. Progressive Crossed-Apraxia of Speech as a First Manifestation of a Probable Corticobasal Degeneration. In: Behavioural neurology, 2012, vol. 25, n° 4, p. 285-289. doi: 10.3233/BEN-2012-110219 https://archive-ouverte.unige.ch/unige:43802

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Deposited on : 2014-12-18

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