Scientific article
Open access

Loci influencing blood pressure identified using a cardiovascular gene-centric array

Published inHuman molecular genetics, vol. 22, no. 8, p. 1663-1678
Publication date2013

Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped ∼50 000 single-nucleotide polymorphisms (SNPs) that capture variation in ∼2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P < 2.4 × 10(-6)). We then replicated these associations in an independent set of 65 886 individuals of European ancestry. The findings from expression QTL (eQTL) analysis showed associations of SNPs in the MDM4 region with MDM4 expression. We did not find any evidence of association of the two novel SNPs in MDM4 and HRH1 with sequelae of high BP including coronary artery disease (CAD), left ventricular hypertrophy (LVH) or stroke. In summary, we identified two novel loci associated with BP and confirmed multiple previously reported associations. Our findings extend our understanding of genes involved in BP regulation, some of which may eventually provide new targets for therapeutic intervention.

  • Adult
  • Aged
  • Blood Pressure/genetics
  • Cardiovascular Diseases/genetics/physiopathology
  • Chromosome Mapping
  • Cohort Studies
  • European Continental Ancestry Group/genetics
  • Female
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
Citation (ISO format)
GANESH, Santhi K, TRAGANTE, Vinicius, GUO, Wei. Loci influencing blood pressure identified using a cardiovascular gene-centric array. In: Human molecular genetics, 2013, vol. 22, n° 8, p. 1663–1678. doi: 10.1093/hmg/dds555
Main files (1)
Article (Published version)
ISSN of the journal0964-6906

Technical informations

Creation08/23/2014 11:23:00 PM
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