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Title

Immunosuppresseurs : usages systémiques et neurologiques

Authors
Schnider, C
Spertini, F
Published in Revue médicale suisse. 2013, vol. 9, no. 384, p. 915-21
Abstract Involvement of the central or peripheral nervous system, frequently present in systemic inflammatory immune disorders, has to be considered a severe threat and requires aggressive immunosuppressive treatment to achieve rapid remission. This is usually obtained with high-dose systemic corticosteroids combined with cyclophosphamide. Once remission is obtained, immunosuppressive agents with a more favorable safety profile are needed to exert a corticosteroid-sparing effect and minimize adverse events. New therapeutic approaches are currently developed to treat autoimmune diseases, mostly linked to the definition of new indications for biological agents such as TNF-alpha antagonists and rituximab.
Keywords Antibodies, Monoclonal/therapeutic useB-Lymphocytes/immunologyHumansImmunosuppressive Agents/therapeutic useNervous System Diseases/drug therapyTumor Necrosis Factor-alpha/antagonists & inhibitors
Identifiers
PMID: 23717900
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Other version: http://rms.medhyg.ch/numero-384-page-915.htm
Structures
Research group Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
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SCHNIDER, C et al. Immunosuppresseurs : usages systémiques et neurologiques. In: Revue médicale suisse, 2013, vol. 9, n° 384, p. 915-21. https://archive-ouverte.unige.ch/unige:43689

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Deposited on : 2014-12-17

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