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Activation of the lectin pathway of complement in pig-to-human xenotransplantation models

Bongoni, Anjan K
Kiermeir, David
Jenni, Hansjörg
Wünsch, Annegret
Bähr, Andrea
Ayares, David
Wolf, Eckhard
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Published in Transplantation. 2013, vol. 96, no. 9, p. 791-9
Abstract Natural IgM containing anti-Gal antibodies initiates classic pathway complement activation in xenotransplantation. However, in ischemia-reperfusion injury, IgM also induces lectin pathway activation. The present study was therefore focused on lectin pathway as well as interaction of IgM and mannose-binding lectin (MBL) in pig-to-human xenotransplantation models.
Keywords AnimalsAnimals, Genetically ModifiedAntigens, CD46/genetics/immunology/metabolismBlood TransfusionCells, CulturedComplement Pathway, Mannose-Binding LectinComplement System Proteins/metabolismEndothelial Cells/immunology/metabolismGalactosyltransferases/deficiency/genetics/immunologyHindlimbHistocompatibilityHumansImmunoglobulin M/metabolismMannose-Binding Lectins/immunology/metabolismMannose-Binding Protein-Associated Serine Proteases/metabolismMuscle, Skeletal/blood supply/immunology/metabolismSwineTime FactorsTransplantation, Heterologous
PMID: 23958924
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Research group Laboratoire d'immunologie translationnelle (856)
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BONGONI, Anjan K et al. Activation of the lectin pathway of complement in pig-to-human xenotransplantation models. In: Transplantation, 2013, vol. 96, n° 9, p. 791-9. doi: 10.1097/TP.0b013e3182a3a52b https://archive-ouverte.unige.ch/unige:43685

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Deposited on : 2014-12-17

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