Activation of the lectin pathway of complement in pig-to-human xenotransplantation models

Bongoni, Anjan K; Kiermeir, David; Jenni, Hansjörg; Wünsch, Annegret; Bähr, Andrea; Ayares, David; Seebach, Jorg Dieter; Wolf, Eckhard; Klymiuk, Nikolai; Constantinescu, Mihai A; Vögelin, Esther; Rieben, Robert

doi:10.1097/TP.0b013e3182a3a52b

Scientific article

English

Activation of the lectin pathway of complement in pig-to-human xenotransplantation models

ContributorsBongoni, Anjan K; Kiermeir, David; Jenni, Hansjörg; Wünsch, Annegret; Bähr, Andrea; Ayares, David; Seebach, Jorg Dieter; Wolf, Eckhard; Klymiuk, Nikolai; Constantinescu, Mihai A; Vögelin, Esther; Rieben, Robert

Published inTransplantation, vol. 96, no. 9, p. 791-799

Publication date2013

Abstract

Natural IgM containing anti-Gal antibodies initiates classic pathway complement activation in xenotransplantation. However, in ischemia-reperfusion injury, IgM also induces lectin pathway activation. The present study was therefore focused on lectin pathway as well as interaction of IgM and mannose-binding lectin (MBL) in pig-to-human xenotransplantation models.

Keywords

Animals
Animals, Genetically Modified
Antigens, CD46/genetics/immunology/metabolism
Blood Transfusion
Cells, Cultured
Complement Pathway, Mannose-Binding Lectin
Complement System Proteins/metabolism
Endothelial Cells/immunology/metabolism
Galactosyltransferases/deficiency/genetics/immunology
Hindlimb
Histocompatibility
Humans
Immunoglobulin M/metabolism
Mannose-Binding Lectins/immunology/metabolism
Mannose-Binding Protein-Associated Serine Proteases/metabolism
Muscle, Skeletal/blood supply/immunology/metabolism
Swine
Time Factors
Transplantation, Heterologous

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Cellules NK et récepteurs FcyR dans l'auto-immunité et le rejet de xénotransplantation (856)

Citation (ISO format)

BONGONI, Anjan K et al. Activation of the lectin pathway of complement in pig-to-human xenotransplantation models. In: Transplantation, 2013, vol. 96, n° 9, p. 791–799. doi: 10.1097/TP.0b013e3182a3a52b

Article (Published version)

Identifiers

PID : unige:43685
DOI : 10.1097/TP.0b013e3182a3a52b
PMID : 23958924

Journal ISSN0041-1337

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Activation of the lectin pathway of complement in pig-to-human xenotransplantation models

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