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Scientific article
English

In vitro demonstration of focused ultrasound thrombolysis using bifrequency excitation

Contributors

Saletes, Izella; Gilles, Bruno; Auboiroux, Vincent; Bendridi, Nadia; Salomir, Rares Vincent; Béra, Jean-Christophe

Published in

BioMed research international, vol. 2014, 518787

Publication date

2014

Abstract

Focused ultrasound involving inertial cavitation has been shown to be an efficient method to induce thrombolysis without any pharmacological agent. However, further investigation of the mechanisms involved and further optimization of the process are still required. The present work aims at studying the relevance of a bifrequency excitation compared to a classical monofrequency excitation to achieve thrombolysis without any pharmacological agent. In vitro human blood clots were placed at the focus of a piezoelectric transducer. Efficiency of the thrombolysis was assessed by weighing each clot before and after sonication. The efficiencies of mono- (550 kHz) and bifrequency (535 and 565 kHz) excitations were compared for peak power ranging from 70 W to 220 W. The thrombolysis efficiency appears to be correlated to the inertial cavitation activity quantified by passive acoustic listening. In the conditions of the experiment, the power needed to achieve 80% of thrombolysis with a monofrequency excitation is reduced by the half with a bifrequency excitation. The thermal effects of bifrequency and monofrequency excitations, studied using MR thermometry measurements in turkey muscle samples where no cavitation occurred, did not show any difference between both types of excitations when using the same power level.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

SALETES, Izella et al. In vitro demonstration of focused ultrasound thrombolysis using bifrequency excitation. In: BioMed research international, 2014, vol. 2014, p. 518787. doi: 10.1155/2014/518787

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

2314-6133
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Technical informations

Creation

17/11/2014 17:36:00

First validation

17/11/2014 17:36:00

Update

14/03/2023 22:29:30

Status update

14/03/2023 22:29:29

Last indexation

30/10/2024 21:34:06
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