UNIGE document Scientific Article
previous document  unige:43442  next document
add to browser collection
Title

A literature-based approach to evaluate the predictive capacity of a marker using time-dependent summary receiver operating characteristics

Authors
Daures, Jp
Foucher, Y
Published in Statistical Methods in Medical Research. 2012
Abstract Meta-analyses are popular tools to summarize the results of publications. Prognostic performances of a marker are usually summarized by meta-analyses of survival curves or hazard ratios. These approaches may detect a difference in survival according to the marker but do not allow evaluation of its prognostic capacity. Time-dependent receiver operating characteristic curves evaluate the ability of a marker to predict time-to-event. In this article, we describe an adaptation of time-dependent summary receiver operating characteristic curves from published survival curves. To achieve this goal, we modeled the marker and the time-to-event distributions using non-linear mixed models. First, we applied this methodology to individual data in kidney transplantation presented as aggregated data, in order to validate the method. Second, we re-analyzed a published meta-analysis, which focused on the capacity of KI-67 to predict the overall survival of patients with breast cancer.
Identifiers
PMID: 23117409
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
Structures
Research group Epidémiologie clinique (115)
Citation
(ISO format)
COMBESCURE, Christophe, DAURES, Jp, FOUCHER, Y. A literature-based approach to evaluate the predictive capacity of a marker using time-dependent summary receiver operating characteristics. In: Statistical Methods in Medical Research, 2012. https://archive-ouverte.unige.ch/unige:43442

160 hits

0 download

Update

Deposited on : 2014-12-15

Export document
Format :
Citation style :