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Steroids for LBP - from rationale to inconvenient truth

Dudler, Jean
Published in Swiss medical weekly. 2012, vol. 142, w13566
Abstract Low back pain (LBP) and sciatica are highly prevalent and their treatment remains a clinical challenge. Systemic or local administration of corticosteroids is frequently prescribed for this indication, partly because its pathogenesis is believed to be a mix between mechanical and inflammatory phenomenon, and because corticosteroids do have some analgesic properties. Although there is some biological and animal data in favour of the use of corticosteroids in LBP and sciatica, clinical evidence remains scarce. Local epidural injection can have some short term benefit. However, we found no support for any type for systemic administration of corticosteroids, a practice that should definitively be banned.
Keywords Analgesics/administration & dosage/therapeutic useAnti-Inflammatory Agents/administration & dosage/therapeutic useGlucocorticoids/administration & dosage/therapeutic useHumansLow Back Pain/drug therapySciatica/drug therapy
PMID: 22495738
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Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
(ISO format)
BALAGUE, Federico, PIGUET, Valérie, DUDLER, Jean. Steroids for LBP - from rationale to inconvenient truth. In: Schweizerische medizinische Wochenschrift, 2012, vol. 142, p. w13566. doi: 10.4414/smw.2012.13566 https://archive-ouverte.unige.ch/unige:43235

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Deposited on : 2014-12-12

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