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Hypothalamic-mediated control of glucose balance in the presence and absence of insulin

Fujikawa, Teppei
Published in Aging. 2014, vol. 6, no. 2, p. 92-7
Abstract Diabetes afflicts hundreds of millions worldwide. People affected by type 1 diabetes mellitus (T1DM; the insulin-deficient form of diabetes) or type 2 diabetes mellitus (T2DM; the insulin-resistant form of diabetes) have significantly reduced life expectancy compared to normal individuals. This is due in part to the fact that (despite improvements) current anti-diabetic approaches are suboptimal. Indeed, severe morbidities (e.g.: cardiovascular disease, hypertension) are still too often associated with diabetes. Recent preclinical results indicate that different types of hypothalamic neurons are endowed with the ability to mediate the hyperglycemia-lowering action of the adipocyte-derived hormone leptin in an insulin-dependent and insulin-independent fashion. These results may pave the way for better anti-diabetic approaches and therefore positively impact on life expectancy of diabetic subjects.
Keywords Aging/metabolismAnimalsDiabetes Mellitus/therapyGlucose/metabolismHumansHypothalamus/physiologyInsulin/physiologyLeptin/physiology
PMID: 24589844
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Research group Groupe Coppari Roberto (physiologie cellulaire et métabolisme) (921)
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FUJIKAWA, Teppei, COPPARI, Roberto. Hypothalamic-mediated control of glucose balance in the presence and absence of insulin. In: Aging, 2014, vol. 6, n° 2, p. 92-7. https://archive-ouverte.unige.ch/unige:43118

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Deposited on : 2014-12-11

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