en
Scientific article
Review
English

Adipokines at the crossroad between obesity and cardiovascular disease

Published inThrombosis and haemostasis, vol. 113, no. 2, p. 553-566
Publication date2015
Abstract

Obesity, and especially excessive visceral adipose tissue accumulation, is considered as a low-grade inflammatory state that is responsible for adipocyte dysfunction and associated metabolic disorders. Adipose tissue displays endocrine functions by releasing pro- or anti-inflammatory bioactive molecules named adipokines. An altered expression of these molecules, provoked by obesity or adipocyte dysregulation, contributes to major metabolic diseases such as insulin resistance and type 2 diabetes mellitus that are important risk factors for cardiovascular disease. However, obesity is also characterised by the expansion of perivascular adipose tissue that acts locally via diffusion of adipokines into the vascular wall. Local inflammation within blood vessels induced by adipokines contributes to the onset of endothelial dysfunction, atherosclerosis and thrombosis, but also to vascular remodelling and hypertension. A fast expansion of obesity is expected in the near future, which will rapidly increase the incidence of these cardiovascular diseases. The focus of this review is to summarise the link between metabolic and cardiovascular disease and discuss current treatment approaches, limitations and future perspectives for more targeted therapies.

Citation (ISO format)
MOLICA, Filippo et al. Adipokines at the crossroad between obesity and cardiovascular disease. In: Thrombosis and haemostasis, 2015, vol. 113, n° 2, p. 553–566. doi: 10.1160/TH14-06-0513
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0340-6245
571views
3downloads

Technical informations

Creation11/03/2014 12:36:00 PM
First validation11/03/2014 12:36:00 PM
Update time03/14/2023 10:24:23 PM
Status update03/14/2023 10:24:23 PM
Last indexation01/16/2024 3:03:23 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack