Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

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Title		Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length
Authors		Chuard, Nicolas Gasparini, Giulio Roux, Aurélien Sakai, Naomi Matile, Stefan
Published in		Organic & biomolecular chemistry. 2015, vol. 13, no. 1, p. 64-67
Abstract		We report that the depolymerization kinetics of cell-penetrating poly(disulfide)s depend exclusively on their length and propose a kinetic uptake model to explain why their intracellular destination changes with the increasing length from the endosomes over the cytosol to the nucleoli.
Identifiers		DOI: 10.1039/C4OB02060J
Full text		Article (Published version) (975 Kb) - Limited access to UNIGE Other version: http://xlink.rsc.org/?DOI=C4OB02060J
Structures		Faculté des sciences / Section de chimie et biochimie / Département de chimie organique Faculté des sciences / Section de chimie et biochimie / Département de biochimie
Citation (ISO format)		CHUARD, Nicolas et al. Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length. In: Organic & biomolecular chemistry, 2015, vol. 13, n° 1, p. 64-67. doi: 10.1039/C4OB02060J https://archive-ouverte.unige.ch/unige:43002

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Deposited on : 2014-12-10

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