Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

Chuard, Nicolas; Gasparini, Giulio; Roux, Aurélien; Sakai, Naomi; Matile, Stefan

doi:10.1039/C4OB02060J

Scientific article

English

Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

ContributorsChuard, Nicolas; Gasparini, Giulio; Roux, Aurélien

; Sakai, Naomi; Matile, Stefan

Published inOrganic & biomolecular chemistry, vol. 13, no. 1, p. 64-67

Publication date2015

Abstract

We report that the depolymerization kinetics of cell-penetrating poly(disulfide)s depend exclusively on their length and propose a kinetic uptake model to explain why their intracellular destination changes with the increasing length from the endosomes over the cytosol to the nucleoli.

Affiliation entities

Citation (ISO format)

CHUARD, Nicolas et al. Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length. In: Organic & biomolecular chemistry, 2015, vol. 13, n° 1, p. 64–67. doi: 10.1039/C4OB02060J

Article (Published version)

Identifiers

PID : unige:43002
DOI : 10.1039/C4OB02060J

Commercial URLhttp://xlink.rsc.org/?DOI=C4OB02060J

Journal ISSN1477-0520

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Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

We report that the depolymerization kinetics of cell-penetrating poly(disulfide)s depend exclusively on their length and propose a kinetic uptake model to explain why their intracellular destination changes with the increasing length from the endosomes over the cytosol to the nucleoli.

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