Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

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Title		Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length
Authors		Chuard, Nicolas Gasparini, Giulio Roux, Aurélien Sakai, Naomi Matile, Stefan
Published in		Organic and Biomolecular Chemistry. 2015, vol. 13, no. 1, p. 64-67
Abstract		We report that the depolymerization kinetics of cell-penetrating poly(disulfide)s depend exclusively on their length and propose a kinetic uptake model to explain why their intracellular destination changes with the increasing length from the endosomes over the cytosol to the nucleoli.
Identifiers		DOI: 10.1039/C4OB02060J
Full text		Article (Published version) (975 Kb) - Limited access to UNIGE Other version: http://xlink.rsc.org/?DOI=C4OB02060J
Structures		Faculté des sciences / Section de chimie et biochimie / Département de chimie organique Faculté des sciences / Section de chimie et biochimie / Département de biochimie
Citation (ISO format)		CHUARD, Nicolas et al. Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length. In: Organic and Biomolecular Chemistry, 2015, vol. 13, n° 1, p. 64-67. doi: 10.1039/C4OB02060J https://archive-ouverte.unige.ch/unige:43002

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Deposited on : 2014-12-10

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