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Title

Smooth muscle cell phenotypic switch: implications for foam cell formation

Authors
Bochaton-Piallat, Marie-Luce
Published in Current Opinion in Lipidology. 2014, vol. 25, no. 5, p. 374-9
Abstract It is well accepted that LDLs and its modified form oxidized-LDL (ox-LDL) play a major role in the development of atherosclerosis and foam cell formation. Whereas the majority of these cells have been demonstrated to be derived from macrophages, smooth muscle cells (SMCs) give rise to a significant number of foam cells as well. During atherosclerotic plaque formation, SMCs switch from a contractile to a synthetic phenotype. The contribution of this process to foam cell formation is still not well understood.
Identifiers
PMID: 25110900
Full text
Article (Published version) (653 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Bochaton-Piallat Marie-Luce (pathologie et immunologie) (646)
Projects
FNS: 310030_146790/1
Autre: Fondation Simone et Gustave Prévot, Fondation Artères
Citation
(ISO format)
CHAABANE, Chiraz, COEN, Matteo, BOCHATON-PIALLAT, Marie-Luce. Smooth muscle cell phenotypic switch: implications for foam cell formation. In: Current Opinion in Lipidology, 2014, vol. 25, n° 5, p. 374-9. doi: 10.1097/MOL.0000000000000113 https://archive-ouverte.unige.ch/unige:42959

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Deposited on : 2014-12-10

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