UNIGE document Scientific Article
previous document  unige:42896  next document
add to browser collection
Title

Profile of circulating cytokines: impact of OSA, obesity and acute cardiovascular events

Authors
Testelmans, Dries
Tamisier, Renaud
Barone-Rochette, Gilles
Baguet, Jean-Philippe
Pépin, Jean-Louis
Lévy, Patrick
Published in Cytokine. 2013, vol. 62, no. 2, p. 210-6
Abstract Obstructive sleep apnea (OSA) is inducing oxidative stress and consequently promotes systemic inflammation and cardiovascular morbidity. The respective impact of obesity, sleep apnea and acute cardiovascular events on the profile of inflammatory cytokines has not been extensively evaluated. We examined the profile of circulating cytokines in a case-control study comparing nonobese or obese patients with or without sleep apnea and with or without an acute cardiovascular event. Patients were assessed by sleep studies and inflammatory (hs-CRP, Leptin, RANTES, MCP1, IL6, IL8, TNF-α) and anti-inflammatory (adiponectin, IL1-Ra) cytokines profile. A cardiovascular phenotyping was performed including carotid intima-media thickness, pulse wave velocity and 24h blood pressure monitoring. In comparison with patients without sleep apnea or without comorbidities, patients with the combination of an acute cardiovascular event and pre-existing sleep apnea showed a higher burden of systemic inflammation with significant increase in serum levels of hs-CRP, IL1-Ra, IL-8, IL-6, TNF-α, Rantes and sICAM. Rantes and sICAM serum levels were independently associated with AHI after an acute cardiovascular event. Serum levels of different inflammatory markers were significantly increased in patients with the combination of sleep apnea and an acute cardiovascular event. Since these biomarkers could be associated with worsened cardiovascular outcome, diagnosing and treating associated sleep apnea is potentially important in patients after an acute cardiovascular event.
Keywords Adiponectin/bloodBiological Markers/bloodCardiovascular Diseases/blood/metabolismCarotid Intima-Media ThicknessCase-Control StudiesCytokines/bloodFemaleHumansInflammationMaleMiddle AgedObesity/blood/metabolismPolysomnographySleep Apnea, Obstructive/blood/metabolism
Identifiers
PMID: 23522821
Full text
Article (Published version) (545 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)
Citation
(ISO format)
TESTELMANS, Dries et al. Profile of circulating cytokines: impact of OSA, obesity and acute cardiovascular events. In: Cytokine, 2013, vol. 62, n° 2, p. 210-6. https://archive-ouverte.unige.ch/unige:42896

181 hits

0 download

Update

Deposited on : 2014-12-09

Export document
Format :
Citation style :