Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice

Chennupati, Ramesh; Meens, Merlijn; Marion, Vincent; Janssen, Ben J; Lamers, Wouter H; De Mey, Jo G R; Köhler, S Eleonore

doi:10.1371/journal.pone.0102264

Scientific article

English

Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice

ContributorsChennupati, Ramesh; Meens, Merlijn; Marion, Vincent; Janssen, Ben J; Lamers, Wouter H; De Mey, Jo G R; Köhler, S Eleonore

Published inPloS one, vol. 9, no. 7, e102264

Publication date2014

Abstract

Argininosuccinate synthetase (ASS) is essential for recycling L-citrulline, the by-product of NO synthase (NOS), to the NOS substrate L-arginine. Here, we assessed whether disturbed arginine resynthesis modulates endothelium-dependent vasodilatation in normal and diabetic male mice.

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research groups

Connexines et pathologies cardiovasculaires (665)

Citation (ISO format)

CHENNUPATI, Ramesh et al. Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice. In: PloS one, 2014, vol. 9, n° 7, p. e102264. doi: 10.1371/journal.pone.0102264

Article (Published version)

CC BY

Identifiers

PID : unige:42871
DOI : 10.1371/journal.pone.0102264
PMID : 25033204

Journal ISSN1932-6203

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Creation29/10/2014 10:35:00

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Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice

Argininosuccinate synthetase (ASS) is essential for recycling L-citrulline, the by-product of NO synthase (NOS), to the NOS substrate L-arginine. Here, we assessed whether disturbed arginine resynthesis modulates endothelium-dependent vasodilatation in normal and diabetic male mice.

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