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The plasma concentration of GABA shows no evidence of a circadian rhythm and is stable over weeks in normal males

Authors
Lloyd, K. G.
Voltz, C.
Lustenberger, S.
Published in Biological Rhythm Research. 1994, vol. 25, no. 3, p. 291-300
Abstract The concentration of free GABA was measured in the plasma of 18 normal young men, in three separa te studies. Overall, it varied by a factor of about 4-fold in normal subjects, from values of 0.10 nmol/ml to 0.40 nmol/ml. Day-to-day stability was found to be very high (r=0.94, n=8 subjects, p<0.002). Free GABA concentration was stable over more than 2 weeks (r=0.95, n=5 subjects, p<0.02). A study of circadian rhythms was carried out (n=5 subjects) comparing a condition with no food and partial light deprivation in a supine position during 34 hr. ("rest" condition") with a condition of normal daily activities ("activity" condition). No circadian rhythm was found in the "rest" condition. In the "activity" condition, there was a mid-day rise in GABA concentrations in 3 out of 5 subjects. The significance of these changes was explored using different statistical tests.
Keywords GABAPlasmaCircadian rhythmHuman
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SCHULZ, Pierre et al. The plasma concentration of GABA shows no evidence of a circadian rhythm and is stable over weeks in normal males. In: Biological Rhythm Research, 1994, vol. 25, n° 3, p. 291-300. https://archive-ouverte.unige.ch/unige:42848

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Deposited on : 2014-12-09

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