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Scientific article
English

The plasma concentration of GABA shows no evidence of a circadian rhythm and is stable over weeks in normal males

Contributors

Schulz, Pierre; Lloyd, K. G.; Voltz, C.; Lustenberger, S.; Degli Agosti, Robert

Published in

Biological rhythm research, vol. 25, no. 3, p. 291-300

Publication date

1994

Abstract

The concentration of free GABA was measured in the plasma of 18 normal young men, in three separa te studies. Overall, it varied by a factor of about 4-fold in normal subjects, from values of 0.10 nmol/ml to 0.40 nmol/ml. Day-to-day stability was found to be very high (r=0.94, n=8 subjects, p<0.002). Free GABA concentration was stable over more than 2 weeks (r=0.95, n=5 subjects, p<0.02). A study of circadian rhythms was carried out (n=5 subjects) comparing a condition with no food and partial light deprivation in a supine position during 34 hr. ("rest" condition") with a condition of normal daily activities ("activity" condition). No circadian rhythm was found in the "rest" condition. In the "activity" condition, there was a mid-day rise in GABA concentrations in 3 out of 5 subjects. The significance of these changes was explored using different statistical tests.

Keywords

  • GABA
  • Plasma
  • Circadian rhythm
  • Human

UNIGE affiliation entities

Citation (ISO format)

SCHULZ, Pierre et al. The plasma concentration of GABA shows no evidence of a circadian rhythm and is stable over weeks in normal males. In: Biological rhythm research, 1994, vol. 25, n° 3, p. 291–300. doi: 10.1080/09291019409360304

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0929-1016
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Technical informations

Creation

05/12/2014 10:30:00

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05/12/2014 10:30:00

Update

14/03/2023 22:23:06

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