Clinical significance of the CCR5delta32 allele in hepatitis C

Morard, Isabelle; Clement, Sophie; Calmy, Alexandra; Mangia, Alessandra; Cerny, Andrea; De Gottardi, Andrea; Gorgievski, Meri; Heim, Markus; Malinverni, Raffaele; Moradpour, Darius; Müllhaupt, Beat; Semela, David; Pascarella Rochat, Stéphanie; Bochud, Pierre-Yves; Negro, Francesco

doi:10.1371/journal.pone.0106424

Scientific article

English

Clinical significance of the CCR5delta32 allele in hepatitis C

ContributorsMorard, Isabelle; Clement, Sophie; Calmy, Alexandra

; Mangia, Alessandra; Cerny, Andrea; De Gottardi, Andrea; Gorgievski, Meri; Heim, Markus; Malinverni, Raffaele; Moradpour, Darius; Müllhaupt, Beat; Semela, David; Pascarella Rochat, Stéphanie; Bochud, Pierre-Yves; Negro, Francesco

Published inPloS one, vol. 9, no. 9, e106424

Publication date2014

Abstract

The CCR5 receptor, expressed on Th1 cells, may influence clinical outcomes of HCV infection. We explored a possible link between a CCR5 32-base deletion (CCR5delta32), resulting in the expression of a non-functioning receptor, and clinical outcomes of HCV infection.

Affiliation entities

Research groups

Etudes et traitement de l'hépatite C et B (554)

Citation (ISO format)

MORARD, Isabelle et al. Clinical significance of the CCR5delta32 allele in hepatitis C. In: PloS one, 2014, vol. 9, n° 9, p. e106424. doi: 10.1371/journal.pone.0106424

Article (Published version)

CC BY

Identifiers

PID : unige:42807
DOI : 10.1371/journal.pone.0106424
PMID : 25191700

Journal ISSN1932-6203

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Creation10/27/2014 12:08:00 PM

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Clinical significance of the CCR5delta32 allele in hepatitis C

The CCR5 receptor, expressed on Th1 cells, may influence clinical outcomes of HCV infection. We explored a possible link between a CCR5 32-base deletion (CCR5delta32), resulting in the expression of a non-functioning receptor, and clinical outcomes of HCV infection.

Technical informations