Scientific article
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Th17 cells favor inflammatory responses while inhibiting type I collagen deposition by dermal fibroblasts: differential effects in healthy and systemic sclerosis fibroblasts

Published inArthritis research & therapy, vol. 15, no. 5, R151
Publication date2013
Abstract

T helper (Th)-17 cells are increased in systemic sclerosis (SSc). We therefore assessed whether Th17 cells could modulate the inflammatory and fibrotic responses in dermal fibroblasts from healthy donors (HD) and SSc individuals.

Keywords
  • Blotting, Western
  • Cells, Cultured
  • Chemokine CCL2/genetics/metabolism
  • Collagen Type I/genetics/metabolism
  • Culture Media, Conditioned/metabolism/pharmacology
  • Dose-Response Relationship, Drug
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fibroblasts/drug effects/metabolism
  • Gene Expression/drug effects
  • Humans
  • Inflammation Mediators/metabolism
  • Interferon-gamma/pharmacology
  • Interleukin-17/pharmacology
  • Interleukin-8/genetics/metabolism
  • Male
  • Matrix Metalloproteinase 1/genetics/metabolism
  • Radioimmunoassay
  • Reverse Transcriptase Polymerase Chain Reaction
  • Scleroderma, Systemic/genetics/metabolism/pathology
  • Skin/metabolism/pathology
  • Th17 Cells/metabolism
  • Tumor Necrosis Factor-alpha/pharmacology
Citation (ISO format)
BREMBILLA, Nicolo et al. Th17 cells favor inflammatory responses while inhibiting type I collagen deposition by dermal fibroblasts: differential effects in healthy and systemic sclerosis fibroblasts. In: Arthritis research & therapy, 2013, vol. 15, n° 5, p. R151. doi: 10.1186/ar4334
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Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN1478-6354
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308downloads

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