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Title

Th17 cells favor inflammatory responses while inhibiting type I collagen deposition by dermal fibroblasts: differential effects in healthy and systemic sclerosis fibroblasts

Authors
Raschi, Elena
Meroni, Pierluigi
Published in Arthritis research & therapy. 2013, vol. 15, no. 5, R151
Abstract T helper (Th)-17 cells are increased in systemic sclerosis (SSc). We therefore assessed whether Th17 cells could modulate the inflammatory and fibrotic responses in dermal fibroblasts from healthy donors (HD) and SSc individuals.
Keywords Blotting, WesternCells, CulturedChemokine CCL2/genetics/metabolismCollagen Type I/genetics/metabolismCulture Media, Conditioned/metabolism/pharmacologyDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayFemaleFibroblasts/drug effects/metabolismGene Expression/drug effectsHumansInflammation Mediators/metabolismInterferon-gamma/pharmacologyInterleukin-17/pharmacologyInterleukin-8/genetics/metabolismMaleMatrix Metalloproteinase 1/genetics/metabolismRadioimmunoassayReverse Transcriptase Polymerase Chain ReactionScleroderma, Systemic/genetics/metabolism/pathologySkin/metabolism/pathologyTh17 Cells/metabolismTumor Necrosis Factor-alpha/pharmacology
Identifiers
PMID: 24289089
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Research group La matrice extracellulaire (651)
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BREMBILLA, Nicolo et al. Th17 cells favor inflammatory responses while inhibiting type I collagen deposition by dermal fibroblasts: differential effects in healthy and systemic sclerosis fibroblasts. In: Arthritis research & therapy, 2013, vol. 15, n° 5, p. R151. doi: 10.1186/ar4334 https://archive-ouverte.unige.ch/unige:42797

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Deposited on : 2014-12-08

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