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Scientific article
Open access
English

Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement

Published inArthritis and rheumatism, vol. 65, no. 5, p. 1347-1356
Publication date2013
Abstract

Levels of interleukin-17A (IL-17A) have been found to be increased in synovial fluid from individuals with systemic sclerosis (SSc). This study was undertaken to investigate whether IL-17A-producing cells are present in affected SSc skin, and whether IL-17A exerts a role in the transdifferentiation of myofibroblasts.

Keywords
  • Adaptive Immunity/immunology
  • Adult
  • Aged
  • Biological Markers/metabolism
  • Cell Count
  • Cell Transdifferentiation
  • Dermis/immunology/metabolism/pathology
  • Female
  • Humans
  • Immunity, Innate/immunology
  • Interleukin-17/immunology/metabolism
  • Male
  • Middle Aged
  • Myofibroblasts/metabolism/pathology
  • Scleroderma, Systemic/immunology/metabolism/pathology
Citation (ISO format)
TRUCHETET, Marie-Elise et al. Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement. In: Arthritis and rheumatism, 2013, vol. 65, n° 5, p. 1347–1356. doi: 10.1002/art.37860
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Article (Published version)
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Identifiers
ISSN of the journal0004-3591
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