Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement

Truchetet, Marie-Elise; Brembilla, Nicolo; Montanari, Elisa; Lonati, Paola; Raschi, Elena; Zeni, Silvana; Fontao, Lionel; Meroni, Pier-Luigi; Chizzolini, Carlo

doi:10.1002/art.37860

Scientific article

English

Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement

ContributorsTruchetet, Marie-Elise; Brembilla, Nicolo; Montanari, Elisa; Lonati, Paola; Raschi, Elena; Zeni, Silvana; Fontao, Lionel; Meroni, Pier-Luigi; Chizzolini, Carlo

Published inArthritis and rheumatism, vol. 65, no. 5, p. 1347-1356

Publication date2013

Abstract

Levels of interleukin-17A (IL-17A) have been found to be increased in synovial fluid from individuals with systemic sclerosis (SSc). This study was undertaken to investigate whether IL-17A-producing cells are present in affected SSc skin, and whether IL-17A exerts a role in the transdifferentiation of myofibroblasts.

Keywords

Adaptive Immunity/immunology
Adult
Aged
Biological Markers/metabolism
Cell Count
Cell Transdifferentiation
Dermis/immunology/metabolism/pathology
Female
Humans
Immunity, Innate/immunology
Interleukin-17/immunology/metabolism
Male
Middle Aged
Myofibroblasts/metabolism/pathology
Scleroderma, Systemic/immunology/metabolism/pathology

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Citation (ISO format)

TRUCHETET, Marie-Elise et al. Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement. In: Arthritis and rheumatism, 2013, vol. 65, n° 5, p. 1347–1356. doi: 10.1002/art.37860

Article (Published version)

Identifiers

PID : unige:42796
DOI : 10.1002/art.37860
PMID : 23335253

Journal ISSN0004-3591

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Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement

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