High IL-17E and low IL-17C dermal expression identifies a fibrosis-specific motif common to morphea and systemic sclerosis

Lonati, Paola Adele; Brembilla, Nicolo; Montanari, Elisa; Fontao, Lionel; Gabrielli, Armando; Vettori, Serena; Valentini, Gabriele; Laffitte, Emmanuel Alexis; Kaya, Guerkan; Meroni, Pier-Luigi; Chizzolini, Carlo

doi:10.1371/journal.pone.0105008

Scientific article

English

High IL-17E and low IL-17C dermal expression identifies a fibrosis-specific motif common to morphea and systemic sclerosis

ContributorsLonati, Paola Adele; Brembilla, Nicolo; Montanari, Elisa; Fontao, Lionel; Gabrielli, Armando; Vettori, Serena; Valentini, Gabriele; Laffitte, Emmanuel Alexis; Kaya, Guerkan; Meroni, Pier-Luigi; Chizzolini, Carlo

Published inPloS one, vol. 9, no. 8, e105008

Publication date2014

Abstract

High interleukin (IL)-17A levels are characteristically found in the skin of systemic sclerosis (SSc) individuals. Our aim was to investigate whether the dermal expression of IL-17A and related IL-17 family members (i.e. IL-17C, IL-17E and IL-17F) could distinguish fibrotic from healthy skin and could show similarities in SSc and morphea, two disorders with presumed distinct pathogenesis, but characterized by skin fibrosis.

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Citation (ISO format)

LONATI, Paola Adele et al. High IL-17E and low IL-17C dermal expression identifies a fibrosis-specific motif common to morphea and systemic sclerosis. In: PloS one, 2014, vol. 9, n° 8, p. e105008. doi: 10.1371/journal.pone.0105008

Article (Published version)

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PID : unige:42690
DOI : 10.1371/journal.pone.0105008
PMID : 25136988

Journal ISSN1932-6203

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High IL-17E and low IL-17C dermal expression identifies a fibrosis-specific motif common to morphea and systemic sclerosis

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