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Title

High IL-17E and low IL-17C dermal expression identifies a fibrosis-specific motif common to morphea and systemic sclerosis

Authors
Lonati, Paola Adele
Gabrielli, Armando
Vettori, Serena
Valentini, Gabriele
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Published in PLOS ONE. 2014, vol. 9, no. 8, p. e105008
Abstract High interleukin (IL)-17A levels are characteristically found in the skin of systemic sclerosis (SSc) individuals. Our aim was to investigate whether the dermal expression of IL-17A and related IL-17 family members (i.e. IL-17C, IL-17E and IL-17F) could distinguish fibrotic from healthy skin and could show similarities in SSc and morphea, two disorders with presumed distinct pathogenesis, but characterized by skin fibrosis.
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PMID: 25136988
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Research groups La matrice extracellulaire (651)
Rôle du CD44 (809)
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LONATI, Paola Adele et al. High IL-17E and low IL-17C dermal expression identifies a fibrosis-specific motif common to morphea and systemic sclerosis. In: PLoS One, 2014, vol. 9, n° 8, p. e105008. https://archive-ouverte.unige.ch/unige:42690

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Deposited on : 2014-12-08

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