UNIGE document Scientific Article
previous document  unige:42525  next document
add to browser collection

Hyperthermia decreases the response to vasoconstrictors in rat portal veins

Published in European Journal of Pharmacology. 2004, vol. 494, no. 2-3, p. 191-7
Abstract The rat portal vein is a useful pharmacological model to study the contractions of smooth muscle cells through both receptor-dependent and receptor-independent mechanisms. We previously showed that sepsis decreases the spontaneous and agonist-induced contractile response to angiotensin II in this model. To determine whether acidosis and hyperthermia, which occur in sepsis, might contribute to this vascular failure, rat portal veins were isolated from control rats and exposed to norepinephrine and angiotensin II. During the pharmacological tests, the rat portal vein were incubated at 37 or 39.5 degrees C or infused with a solution at low pH with normal or high pCO(2). Mild and severe acidosis had minor effects on the vascular response of rat portal vein to norepinephrine and angiotensin II. In contrast, hyperthermia decreased the response of both drugs. Nitric oxide (NO), carbon monoxide (CO), and prostaglandins were not responsible for the decreased response. Thus, acidosis observed during sepsis is not responsible for the vascular dysfunction of rat portal vein. In contrast, hyperthermia participates to the vascular failure but the mediator responsible remains unknown.
Keywords Acidosis/physiopathologyAngiotensin II/pharmacologyAnimalsFever/physiopathologyHypercapnia/physiopathologyMaleMuscle Contraction/drug effectsMuscle, Smooth, Vascular/drug effectsNorepinephrine/pharmacologyPortal Vein/drug effectsRatsRats, Sprague-DawleyVasoconstrictor Agents/pharmacology
PMID: 15212974
Full text
Article (Published version) (245 Kb) - public document Free access
Research group Pharmacologie et imagerie du foie (664)
(ISO format)
PASTOR, Catherine. Hyperthermia decreases the response to vasoconstrictors in rat portal veins. In: European Journal of Pharmacology, 2004, vol. 494, n° 2-3, p. 191-7. https://archive-ouverte.unige.ch/unige:42525

255 hits



Deposited on : 2014-12-04

Export document
Format :
Citation style :