Model-based analysis of Gd-BOPTA-induced MR signal intensity changes in cirrhotic rat livers

Planchamp Messeiller, Corinne; Gex-Fabry, Marianne; Becker, Christoph; Pastor, Catherine

doi:10.1097/RLI.0b013e318036b450

Scientific article

English

Model-based analysis of Gd-BOPTA-induced MR signal intensity changes in cirrhotic rat livers

ContributorsPlanchamp Messeiller, Corinne; Gex-Fabry, Marianne; Becker, Christoph; Pastor, Catherine

Published inInvestigative radiology, vol. 42, no. 7, p. 513-521

Publication date2007

Abstract

To quantify the hepatic transport of the hepatobiliary contrast agent gadobenate dimeglumine (Gd-BOPTA) in rats with biliary cirrhosis of various severity degrees from magnetic resonance (MR) signal intensities using a population pharmacokinetic approach.

Keywords

Animals
Contrast Media
Gadolinium DTPA
Liver/pathology
Liver Cirrhosis/diagnosis/pathology
Magnetic Resonance Imaging
Meglumine/analogs & derivatives
Models, Animal
Organometallic Compounds
Perfusion
Rats
Rats, Sprague-Dawley
Sulfobromophthalein

Affiliation entities

Research groups

Pharmacologie et imagerie du foie (664)

Citation (ISO format)

PLANCHAMP MESSEILLER, Corinne et al. Model-based analysis of Gd-BOPTA-induced MR signal intensity changes in cirrhotic rat livers. In: Investigative radiology, 2007, vol. 42, n° 7, p. 513–521. doi: 10.1097/RLI.0b013e318036b450

Article (Published version)

Identifiers

PID : unige:42523
DOI : 10.1097/RLI.0b013e318036b450
PMID : 17568274

Journal ISSN0020-9996

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Model-based analysis of Gd-BOPTA-induced MR signal intensity changes in cirrhotic rat livers

To quantify the hepatic transport of the hepatobiliary contrast agent gadobenate dimeglumine (Gd-BOPTA) in rats with biliary cirrhosis of various severity degrees from magnetic resonance (MR) signal intensities using a population pharmacokinetic approach.

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