• Home
  1. Home
  2. Influence of gait loads on implant integration in rat tibiae: Experimental and numerical analysis
Scientific article
English

Influence of gait loads on implant integration in rat tibiae: Experimental and numerical analysis

Contributors

Piccinini, Marco; Cugnoni, Joël; Botsis, John; Ammann, Patrick; Wiskott, Anselm

Published in

Journal of biomechanics, vol. 47, no. 13, p. 3255-3263

Publication date

2014

Abstract

Implanted rat bones play a key role in studies involving fracture healing, bone diseases or drugs delivery among other themes. In most of these studies the implants integration also depends on the animal daily activity and musculoskeletal loads, which affect the implants mechanical environment. However, the tissue adaption to the physiological loads is often filtered through control groups or not inspected. This work aims to investigate experimentally and numerically the effects of the daily activity on the integration of implants inserted in the rat tibia, and to establish a physiological loading condition to analyse the peri-implant bone stresses during gait. Two titanium implants, single and double cortex crossing, are inserted in the rat tibia. The animals are caged under standard conditions and divided in three groups undergoing progressive integration periods. The results highlight a time-dependent increase of bone samples with significant cortical bone loss. The phenomenon is analysed through specimen-specific Finite Element models involving purpose-built musculoskeletal loads. Different boundary conditions replicating the post-surgery bone-implant interaction are adopted. The effects of the gait loads on the implants integration are quantified and agree with the results of the experiments. The observed cortical bone loss can be considered as a transient state of integration due to bone disuse atrophy, initially triggered by a loss of bone-implant adhesion and subsequently by a cyclic opening of the interface

Keywords

  • Bone loss
  • Finite element
  • Implant integration
  • Musculoskeletal loads
  • Rat
  • Tibia

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

PICCININI, Marco et al. Influence of gait loads on implant integration in rat tibiae: Experimental and numerical analysis. In: Journal of biomechanics, 2014, vol. 47, n° 13, p. 3255–3263. doi: 10.1016/j.jbiomech.2014.08.023

Main files (1)

Article (Published version)

Identifiers

Additional URL for this publication

http://linkinghub.elsevier.com/retrieve/pii/S002192901400459X

Journal ISSN

0021-9290
647views
0downloads

Technical informations

Creation

15/10/2014 17:02:00

First validation

15/10/2014 17:02:00

Update

14/03/2023 22:20:34

Status update

14/03/2023 22:20:33

Last indexation

30/10/2024 21:02:06
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated