UNIGE document Scientific Article
previous document  unige:42031  next document
add to browser collection
Title

Outcomes of combined liver-kidney transplantation in children: analysis of the scientific registry of transplant recipients

Authors
Published in American Journal of Transplantation. 2014, vol. 14, no. 12, p. 2861-8
Abstract Combined liver-kidney transplantation (CLKT) in children is uncommon and outcomes have not been well defined. Using the Scientific Registry of Transplant Recipients, data were analyzed on 152 primary pediatric CLKTs performed from October 1987 to February 2011, to determine their outcome in the largest series reported to date. Patient survival was 86.8%, 82.1% and 78.9% at 1, 5 and 10 years, liver graft survival was 81.9%, 76.5% and 72.6%, and kidney graft survival was 83.4%, 76.5% and 66.8%. By way of comparison, the Registry was queried for pediatric patient survival following isolated liver transplantation (LT) during the same time frame: 86.7%, 81.2% and 77.4% and following isolated kidney transplant (KT): 98.2%, 95.4% and 90% at 1, 5 and 10 years. In patients having undergone CLKT, primary hyperoxaluria was associated with reduced patient (p = 0.01), liver graft (p = 0.01) and kidney graft survival (p = 0.01). Furthermore, graft outcome following CLKT improved over the past decade (p = 0.04 for liver, p = 0.02 for kidney), but this did not translate into improved patient outcome (p = 0.2). All in all, our results confirmed that survival following LT was less than following KT, and that CLKT offered similar patient survival to isolated LT.
Identifiers
PMID: 25274400
Full text
Article (Published version) (353 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Transplantation et hépatologie (905)
Recherche clinique en chirurgie pédiatrique (886)
Développement du tube digestif chez les vertébrés (900)
Citation
(ISO format)
CALINESCU-TULEASCA, Ana Maria et al. Outcomes of combined liver-kidney transplantation in children: analysis of the scientific registry of transplant recipients. In: American Journal of Transplantation, 2014, vol. 14, n° 12, p. 2861-8. https://archive-ouverte.unige.ch/unige:42031

240 hits

1 download

Update

Deposited on : 2014-11-20

Export document
Format :
Citation style :