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Scientific article
Open access
English

Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation

Published inThe Journal of infectious diseases, vol. 189, no. 9, p. 1628-1633
Publication date2004
Abstract

Tissue-invasive disease due to porcine cytomegalovirus (PCMV) has been demonstrated after pig-to-baboon solid-organ xenotransplantation. Porcine lymphotropic herpesvirus (PLHV)-1 is associated with B cell proliferation and posttransplant lymphoproliferative disorder after allogeneic bone marrow transplantation in swine but has not been observed in pig-to-primate xenotransplantation. Activation of PCMV and PLHV-1 was investigated in 22 pig-to-baboon xenotransplants by use of quantitative polymerase chain reaction. PCMV was found in all xenografts; increased viral replication occurred in 68% of xenografts during immunosuppression. PLHV-1 was found in 12 xenografts (55%); no increases in viral replication occurred during immunosuppression. Control immunosuppressed swine coinfected with PCMV and PLHV-1 had activation of PCMV but not PLHV-1. PCMV, but not PLHV-1, is activated in solid-organ xenotransplantation.

Keywords
  • Animals
  • Animals, Genetically Modified
  • Cytomegalovirus/genetics/isolation & purification/physiology
  • Cytomegalovirus Infections/veterinary/virology
  • DNA, Viral/analysis
  • Gammaherpesvirinae/genetics/isolation & purification/physiology
  • Herpesviridae Infections/veterinary/virology
  • Organ Transplantation/adverse effects
  • Papio/virology
  • Swine/virology
  • Swine, Miniature/virology
  • Transplantation, Heterologous/adverse effects
  • Virus Activation
Citation (ISO format)
MUELLER, Nicolas J et al. Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation. In: The Journal of infectious diseases, 2004, vol. 189, n° 9, p. 1628–1633. doi: 10.1086/383351
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0022-1899
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