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Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation

Mueller, Nicolas J
Livingston, Christine
Knosalla, Christoph
Barth, Rolf N
Yamamoto, Shin
Gollackner, Bernd
Dor, Frank J M F
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Published in The Journal of infectious diseases. 2004, vol. 189, no. 9, p. 1628-33
Abstract Tissue-invasive disease due to porcine cytomegalovirus (PCMV) has been demonstrated after pig-to-baboon solid-organ xenotransplantation. Porcine lymphotropic herpesvirus (PLHV)-1 is associated with B cell proliferation and posttransplant lymphoproliferative disorder after allogeneic bone marrow transplantation in swine but has not been observed in pig-to-primate xenotransplantation. Activation of PCMV and PLHV-1 was investigated in 22 pig-to-baboon xenotransplants by use of quantitative polymerase chain reaction. PCMV was found in all xenografts; increased viral replication occurred in 68% of xenografts during immunosuppression. PLHV-1 was found in 12 xenografts (55%); no increases in viral replication occurred during immunosuppression. Control immunosuppressed swine coinfected with PCMV and PLHV-1 had activation of PCMV but not PLHV-1. PCMV, but not PLHV-1, is activated in solid-organ xenotransplantation.
Keywords AnimalsAnimals, Genetically ModifiedCytomegalovirus/genetics/isolation & purification/physiologyCytomegalovirus Infections/veterinary/virologyDNA, Viral/analysisGammaherpesvirinae/genetics/isolation & purification/physiologyHerpesviridae Infections/veterinary/virologyOrgan Transplantation/adverse effectsPapio/virologySwine/virologySwine, Miniature/virologyTransplantation, Heterologous/adverse effectsVirus Activation
PMID: 15116299
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Research group Cultures cellulaires et transplantations (519)
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MUELLER, Nicolas J et al. Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation. In: The Journal of infectious diseases, 2004, vol. 189, n° 9, p. 1628-33. doi: 10.1086/383351 https://archive-ouverte.unige.ch/unige:41992

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Deposited on : 2014-11-19

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