Professional article

CRF system and mood disorders

ContributorsAubry, Jean-Michel
Published inJournal of chemical neuroanatomy, vol. 54, p. 20-24
Publication date2013

Since CRF discovery, there has been an impressive accumulation of data regarding the role of the CRF system in the regulation of the stress response. The link between stress and induction of a mood episode in the context of unipolar or bipolar disorder has been clearly demonstrated in several studies and is confirmed by clinical practice, particularly in bipolar disorder. Antidepressant-like effects of CRFR1 antagonists in different animal models of depression have generated a strong interest in the clinical development of CRFR1 antagonist for the treatment of major depressive disorder. These efforts have so far not been rewarded by clinical efficacy. However, this therapeutic approach is still being explored. Finally, the accumulated genetic findings, mostly those related to variants within CRFR1, point to a role of the CRF system in the pathophysiology of depression and anxiety.

  • Animals
  • Corticotropin-Releasing Hormone/metabolism
  • Humans
  • Mood Disorders/metabolism/physiopathology
  • Receptors, Corticotropin-Releasing Hormone/metabolism
  • Stress, Physiological/physiology
  • Stress, Psychological/metabolism
Citation (ISO format)
AUBRY, Jean-Michel. CRF system and mood disorders. In: Journal of chemical neuroanatomy, 2013, vol. 54, p. 20–24. doi: 10.1016/j.jchemneu.2013.09.003
Main files (1)
Article (Published version)
ISSN of the journal0891-0618

Technical informations

Creation10/07/2014 11:05:00 AM
First validation10/07/2014 11:05:00 AM
Update time03/14/2023 10:15:03 PM
Status update03/14/2023 10:15:02 PM
Last indexation08/29/2023 1:05:52 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack