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Regulatory effects of interleukin (IL)-1, interferon-beta, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissue

Giusti, Vittorio
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Published in Journal of Clinical Endocrinology and Metabolism. 2004, vol. 89, no. 6, p. 2652-8
Abstract Adipose tissue is the source of production and site of action of several pro- and antiinflammatory cytokines. We have recently shown that white adipose tissue (WAT) is a major producer of the antiinflammatory IL-1 receptor antagonist (IL-1Ra). Because IL-1Ra serum levels are elevated 7-fold in human obesity and an excess of this protein has been implicated in the acquired resistance to leptin and insulin, we investigated the regulation of IL-1Ra in human WAT. We demonstrate that IL-1Ra is mainly produced by adipocytes, rather than the stromal fraction of WAT, and that IL-1alpha and beta, as well as interferon-beta (IFN-beta), strongly up-regulate the expression and secretion of IL-1Ra in WAT. Moreover, human WAT expresses the receptors and proteins known to be required for the action of IL-1 (IL-1 receptor type I, IL-1 receptor accessory protein) and IFN-beta (IFN-alpha/beta receptor subunits 1 and 2). Finally, human WAT actively secretes these regulatory cytokines, suggesting that they up-regulate IL-1Ra through a local autocrine/paracrine action, which is hypothesized to play a regulatory role in adipogenesis and metabolism.
Keywords Adipocytes/drug effects/metabolism/secretionAdipose Tissue/cytology/drug effects/metabolismCells, CulturedDose-Response Relationship, DrugGene Expression/physiologyHumansImmunologic Factors/genetics/pharmacologyInterferon-beta/genetics/pharmacologyInterleukin 1 Receptor Antagonist ProteinInterleukin-1/genetics/pharmacologyInterleukin-4/genetics/pharmacologySialoglycoproteins/genetics/metabolism/secretionStromal Cells/drug effects/metabolism/secretion
PMID: 15181037
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Research groups Groupe Pittet Cuenod Brigitte (chirurgie plastique et reconstructive) (96)
Inflammation et allergie (874)
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JUGE, Cristiana Enrica et al. Regulatory effects of interleukin (IL)-1, interferon-beta, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissue. In: Journal of Clinical Endocrinology and Metabolism, 2004, vol. 89, n° 6, p. 2652-8. doi: 10.1210/jc.2003-031219 https://archive-ouverte.unige.ch/unige:41785

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Deposited on : 2014-11-13

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