Scientific article

Risk factors for early and late biliary complications in pediatric liver transplantation

Published inPediatric transplantation, vol. 18, no. 8, p. 822-830
Publication date2014

BC are a common source of morbidity after pediatric LT. Knowledge about risk factors may help to reduce their incidence. Retrospective analysis of BC in 116 pediatric patients (123 LT) (single institution, 05/1990-12/2011, medium follow-up 7.9 yr). One-, five-, and 10-yr survival was 91.1%, no patient died of BC. Prevalence and risk factors for anastomotic and intrahepatic BC were examined. There were 29 BC in 123 LT (23.6%), with three main categories: 10 (8.1%) primary anastomotic strictures, eight (6.5%) anastomotic leaks, and three (2.4%) intrahepatic strictures. Significant risk factors for anastomotic leaks were total operation time (increase 1.26-fold) and early HAT (<30 days post-LT; increase 5.87-fold). Risk factor for primary anastomotic stricture was duct-to-duct choledochal anastomosis (increase 5.96-fold when compared to biliary-enteric anastomosis). Risk factors for intrahepatic strictures were donor age >48 yr (increase 1.09-fold) and MELD score >30 (increase 1.2-fold). To avoid morbidity from anastomotic BC in pediatric LT, the preferred biliary anastomosis appears to be biliary-enteric. Operation time should be kept to a minimum, and HAT must by all means be prevented. Children with a high MELD score or receiving livers from older donors are at increased risk for intrahepatic strictures.

Citation (ISO format)
LÜTHOLD, Samuel et al. Risk factors for early and late biliary complications in pediatric liver transplantation. In: Pediatric transplantation, 2014, vol. 18, n° 8, p. 822–830. doi: 10.1111/petr.12363
Main files (1)
Article (Published version)
ISSN of the journal1397-3142

Technical informations

Creation11/11/2014 3:00:00 PM
First validation11/11/2014 3:00:00 PM
Update time03/14/2023 10:14:24 PM
Status update03/14/2023 10:14:23 PM
Last indexation10/18/2023 8:27:52 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack