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GluN3A: an NMDA receptor subunit with exquisite properties and functions

Kehoe, Laura A
Published in Neural plasticity. 2013, vol. 2013, 145387
Abstract N-methyl-D-aspartate receptors (NMDAR) are pivotal for synaptic plasticity and memory formation. Conventional NMDAR consist of heterotetrameric structures composed of GluN1 and GluN2 subunits. A third subunit, GluN3, can also assemble with NMDAR subunits giving a remarkable modification of their heteromeric structure, forming a "nonconventional" NMDAR. As a consequence, the stoichiometry and kinetic properties of the receptors are dramatically changed. Among the GluN3 family, the GluN3A subunit has been the focus of a large amount of studies during recent years. These studies reveal that GluN3A is transiently expressed during development and could play a role in the fine tuning of neuronal networks as well as associated diseases. Moreover, GluN3A distribution outside the postsynaptic densities, including perisynaptic astrocytes, places it at a strategic position to play an important role in the interactions between neurons and glial cells. This review highlights GluN3A properties and addresses its role in neurophysiology and associated pathologies.
Keywords AnimalsAstrocytes/physiologyDendritic Spines/physiologyGene Expression/physiologyHumansNerve Tissue Proteins/metabolismNervous System Diseases/genetics/physiopathologyReceptors, N-Methyl-D-Aspartate/biosynthesis/chemistry/genetics/physiology
PMID: 24386575
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Article (Accepted version) (1.3 MB) - public document Free access
Research group Plasticité des synapses excitatrices (76)
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KEHOE, Laura A, BERNARDINELLI, Yann, MULLER, Dominique. GluN3A: an NMDA receptor subunit with exquisite properties and functions. In: Neural plasticity, 2013, vol. 2013, p. 145387. doi: 10.1155/2013/145387 https://archive-ouverte.unige.ch/unige:41707

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Deposited on : 2014-11-12

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