Scientific article
Open access

GluN3A: an NMDA receptor subunit with exquisite properties and functions

Published inNeural plasticity, vol. 2013, 145387
Publication date2013

N-methyl-D-aspartate receptors (NMDAR) are pivotal for synaptic plasticity and memory formation. Conventional NMDAR consist of heterotetrameric structures composed of GluN1 and GluN2 subunits. A third subunit, GluN3, can also assemble with NMDAR subunits giving a remarkable modification of their heteromeric structure, forming a "nonconventional" NMDAR. As a consequence, the stoichiometry and kinetic properties of the receptors are dramatically changed. Among the GluN3 family, the GluN3A subunit has been the focus of a large amount of studies during recent years. These studies reveal that GluN3A is transiently expressed during development and could play a role in the fine tuning of neuronal networks as well as associated diseases. Moreover, GluN3A distribution outside the postsynaptic densities, including perisynaptic astrocytes, places it at a strategic position to play an important role in the interactions between neurons and glial cells. This review highlights GluN3A properties and addresses its role in neurophysiology and associated pathologies.

  • Animals
  • Astrocytes/physiology
  • Dendritic Spines/physiology
  • Gene Expression/physiology
  • Humans
  • Nerve Tissue Proteins/metabolism
  • Nervous System Diseases/genetics/physiopathology
  • Receptors, N-Methyl-D-Aspartate/biosynthesis/chemistry/genetics/physiology
Citation (ISO format)
KEHOE, Laura A, BERNARDINELLI, Yann, MULLER, Dominique. GluN3A: an NMDA receptor subunit with exquisite properties and functions. In: Neural plasticity, 2013, vol. 2013, p. 145387. doi: 10.1155/2013/145387
Main files (1)
Article (Accepted version)
ISSN of the journal1687-5443

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