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Scientific Article - Review
unige:41707 
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GluN3A: an NMDA receptor subunit with exquisite properties and functions |
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| Authors | ||
| Published in | Neural Plasticity. 2013, vol. 2013, 145387 | |
| Abstract | N-methyl-D-aspartate receptors (NMDAR) are pivotal for synaptic plasticity and memory formation. Conventional NMDAR consist of heterotetrameric structures composed of GluN1 and GluN2 subunits. A third subunit, GluN3, can also assemble with NMDAR subunits giving a remarkable modification of their heteromeric structure, forming a "nonconventional" NMDAR. As a consequence, the stoichiometry and kinetic properties of the receptors are dramatically changed. Among the GluN3 family, the GluN3A subunit has been the focus of a large amount of studies during recent years. These studies reveal that GluN3A is transiently expressed during development and could play a role in the fine tuning of neuronal networks as well as associated diseases. Moreover, GluN3A distribution outside the postsynaptic densities, including perisynaptic astrocytes, places it at a strategic position to play an important role in the interactions between neurons and glial cells. This review highlights GluN3A properties and addresses its role in neurophysiology and associated pathologies. | |
| Keywords | Animals — Astrocytes/physiology — Dendritic Spines/physiology — Gene Expression/physiology — Humans — Nerve Tissue Proteins/metabolism — Nervous System Diseases/genetics/physiopathology — Receptors, N-Methyl-D-Aspartate/biosynthesis/chemistry/genetics/physiology | |
| Identifiers | DOI: 10.1155/2013/145387 PMID: 24386575 | |
| Full text | ||
| Structures | ||
| Research group | Plasticité des synapses excitatrices (76) | |
| Citation (ISO format) | KEHOE, Laura A, BERNARDINELLI, Yann, MULLER, Dominique. GluN3A: an NMDA receptor subunit with exquisite properties and functions. In: Neural Plasticity, 2013, vol. 2013, p. 145387. doi: 10.1155/2013/145387 https://archive-ouverte.unige.ch/unige:41707 |
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